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Nodal Signaling & Left-Right Asymmetry


Marjoram L, Wright C. Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus. Development (Cambridge, England). 2011 Feb;138(3). 475-85.
PMID: 21205792 [PubMed].
PMCID: PMC3014634.


Westmoreland JJ, Takahashi S, Wright CV. Xenopus Lefty requires proprotein cleavage but not N-linked glycosylation to inhibit nodal signaling. Developmental dynamics : an official publication of the American Association of Anatomists. 2007 Aug;236(8). 2050-61.
PMID: 17584861 [PubMed].

Ohi Y, Wright CV. Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus. Developmental biology. 2007 Jan 15;301(2). 447-63.
PMID: 16959238 [PubMed].
PMCID: PMC2567117.


Takahashi S, Onuma Y, Yokota C, Westmoreland JJ, Asashima M, Wright CV. Nodal-related gene Xnr5 is amplified in the Xenopus genome. Genesis (New York, N.Y. : 2000). 2006 Jul;44(7). 309-21.
PMID: 16791846 [PubMed].

Cha YR, Takahashi S, Wright CV. Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus. Developmental biology. 2006 Feb 15;290(2). 246-64.
PMID: 16405884 [PubMed].


Wright CV, Halpern ME. Specification of left-right asymmetry. Results and problems in cell differentiation. 40. 96-116.
PMID: 12353488 [PubMed].


Cheng AM, Thisse B, Thisse C, Wright CV. The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus. Development (Cambridge, England). 2000 Mar;127(5). 1049-61.
PMID: 10662644 [PubMed].


Osada SI, Wright CV. Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. Development (Cambridge, England). 1999 Jun;126(14). 3229-40.
PMID: 10375512 [PubMed].


Sampath K, Cheng AM, Frisch A, Wright CV. Functional differences among Xenopus nodal-related genes in left-right axis determination. Development (Cambridge, England). 1997 Sep;124(17). 3293-302.
PMID: 9310324 [PubMed].


Lowe LA, Supp DM, Sampath K, Yokoyama T, Wright CV, Potter SS, Overbeek P, Kuehn MR. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature. 1996 May 9;381(6578). 158-61.
PMID: 8610013 [PubMed].


Jones CM, Kuehn MR, Hogan BL, Smith JC, Wright CV. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development (Cambridge, England). 1995 Nov;121(11). 3651-62.
PMID: 8582278 [PubMed].