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Beta-Cell/Pancreas Biology


Liu J, Willet SG, Bankaitis ED, Xu Y, Wright CV, Gu G. Non-parallel recombination limits cre-loxP-based reporters as precise indicators of conditional genetic manipulation. Genesis (New York, N.Y. : 2000). 2013 Jun;51(6). 436-42.
PMID: 23441020 [PubMed].
PMCID: PMC3696028.

Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (Cambridge, England). 2013 Feb;140(4). 751-64.
PMID: 23325761 [PubMed].
PMCID: PMC3557774.


Rieck S, Bankaitis ED, Wright CV. Lineage determinants in early endocrine development. Seminars in cell & developmental biology. 2012 Aug;23(6). 673-84.
PMID: 22728667 [PubMed].

Willet S, Wright C. Pancreatic Plasticity and Reprogramming: Novel Directions Towards Disease Therapy Nuclear Reprogramming and Stem Cells. Humana Press; 193 – 215.
Nuclear Reprogramming and Stem Cells


Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV. Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. Genes & development. 2011 Aug 15;25(16). 1680-5.
PMID: 21852533 [PubMed].
PMCID: PMC3165933.

Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Developmental dynamics : an official publication of the American Association of Anatomists. 2011 Mar;240(3). 530-65.
PMID: 21337462 [PubMed].


Yang YP, Wright C. Chemicals turn human embryonic stem cells towards beta cells. Nature chemical biology. 2009 Apr;5(4). 195-6.
PMID: 19295520 [PubMed].


Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV. pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Developmental biology. 2008 Feb 15;314(2). 406-17.
PMID: 18155690 [PubMed].
PMCID: PMC2269701.


Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magnuson MA, Xiang M, Wright CV. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development (Cambridge, England). 2006 Nov;133(22). 4439-50.
PMID: 17075007 [PubMed].

Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Developmental biology. 2006 Oct 15;298(2). 616-31.
PMID: 16962573 [PubMed].

Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes & development. 2006 Jan 15;20(2). 253-66.
PMID: 16418487 [PubMed].
PMCID: PMC1356115.


Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nature genetics. 2002 Sep;32(1). 128-34.
PMID: 12185368 [PubMed].