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Winder Lab

Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice.

AUTHORS

Schramm-Sapyta NLNicole L , Pratt AR Adeola R , Winder DG Danny G . Psychopharmacology. 2004 4 ; 173(1-2). 41-8

ABSTRACT

Age of initial exposure to addictive substances is inversely proportional to risk of developing drug dependence. There is debate, however, as to whether intake at a young age causes dependency or whether young people who experiment with addictive substances are predisposed to dependency by other factors. OBJECTIVES. We tested the relationship between cocaine exposure at two different ages in mice and the development of subsequent drug-seeking behavior to test for age-specific exposure effects.