Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound.
AUTHORS
Mueller
RRalf ,
Dawson
ES Eric S ,
Meiler
J Jens ,
Rodriguez
AL Alice L ,
Chauder
BA Brian A ,
Bates
BS Brittney S ,
Felts
AS Andrew S ,
Lamb
JP Jeffrey P ,
Menon
UN Usha N ,
Jadhav
SB Sataywan B ,
Kane
AS Alexander S ,
Jones
CK Carrie K ,
Gregory
KJ Karen J ,
Niswender
CM Colleen M ,
Conn
PJ P Jeffrey ,
Olsen
CM Christopher M ,
Winder
DG Danny G ,
Emmitte
KA Kyle A ,
Lindsley
CW Craig W .
ChemMedChem. 2012 3 5; 7(3).
406-14
- PMID: 22267125[PubMed].
- PMCID: PMC3517057.
- NIHMSID: NIHMS416239