β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism.
AUTHORS
Nobis
WPWilliam P ,
Kash
TL Thomas L ,
Silberman
Y Yuval ,
Winder
DG Danny G .
Biological psychiatry. 2011 6 1; 69(11).
1083-90
- PMID: 21334600[PubMed].
- PMCID: PMC3090515.
- NIHMSID: NIHMS262731
ABSTRACT
Evidence suggests that the noradrenergic and corticotrophin-releasing factor (CRF) systems play critical roles in relapse and stress-related behaviors. In particular, behavioral studies point to a serial signaling process initiated by β-adrenergic receptors that requires CRF receptor (CRFR)-dependent signaling in the bed nucleus of the stria terminalis (BNST) to produce stress-induced relapse to cocaine seeking.