{"id":199,"date":"2021-08-05T22:02:23","date_gmt":"2021-08-05T22:02:23","guid":{"rendered":"https:\/\/lab.prd.vanderbilt.edu\/walker-lab\/?page_id=199"},"modified":"2024-07-12T19:31:18","modified_gmt":"2024-07-12T19:31:18","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.vanderbilt.edu\/walker-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

 
\nHighlighted Publications:<\/strong><\/p>\n

    \n
  1. Ancajas, C.M.F, Oyedele, A., Butt, C., Walker, A.S.<\/strong>, Advances, Opportunities, and Challenges in the Study of Structure Activity Relationships of Natural Products.<\/em> 2024. Natural Product Reports. https:\/\/doi.org\/10.1039\/D4NP00009A<\/a><\/li>\n

    <\/p>\n

  2. Mabesoone, M.F.J., Leopold-Messer, S., Minas, H.A., Chepkirui, C., Chawengrum, P., Reiter, S., Meoded, R.A., Wolf, S., Genz, F., Magnus, N., Piechulla, B., Walker, A.S.<\/strong>, Piel, J. Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases.<\/em> Science. 2024. 383 (6689). 1312-1317.https:\/\/www.science.org\/doi\/abs\/10.1126\/science.adj7621<\/a><\/li>\n

    <\/p>\n

  3. Riedling, O., Walker, A.S.<\/strong>, Rokas, A. Predicting fungal secondary metabolite activity from biosynthetic gene cluster data using machine learning.<\/em> Microbiology Spectrum. 2024. 12 (2). e034990-23
    https:\/\/journals.asm.org\/doi\/full\/10.1128\/spectrum.03400-23<\/a> <\/li>\n

    <\/p>\n

  4. Beck, M.L., Song, S., Shuster, I.E., Miharia, A.,Walker, A.S.<\/strong> Diversity and taxonomic distribution of bacterial biosynthetic gene clusters predicted to produce compounds with therapeutically relevant bioactivities.<\/em> Journal of Industrial Microbiology and Biotechnology. 2023. 50 (1). kuad024.https:\/\/academic.oup.com\/jimb\/article\/50\/1\/kuad024\/7257554<\/a><\/li>\n

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  5. Mullowney, M.W., Duncan, K.R., Elsayed, S.S., Garg, N.,van der Hooft, J.J.J., Martin, M.I., Meijer, D., Terlouw, B.R., Biermann, F., Blin, K.; Durairaj, J., Gorostiola Gonz\u00e1lez, M., Helfrich, E.J.N., Huber, F., Leopold-Messer, S., Rajan, K., de Rond, T., van Santen, J.A., Sorokina, M., Balunas, M.J., Beniddir, M., van Bergeijk, D., Carroll, L.M., Clark, C.M., Clevert, D., Dejong, C.A., Du, C., Ferrinho, S., Grisoni, F., Hofstetter, A., Jespers, W., Kalinina, O.V., Kautsar, S.A., Kim, H., Leao, T.F., Masschelein, J., Rees, E.R., Reher, R., Reker, D., Schwaller, P., Segler, M., Skinnider, M.A., Walker, A.S.<\/strong>, Willighagen, E.L., Zdrazil, B., Ziemert, N., Goss, R.J.M., Guyomard, P., Volkamer, A., Gerwick, W.H., Kim, H., M\u00fcller, R., van Wezel, G.P., van Westen, G., Hirsch, A.K.H., Linington, R.G., Robinson, S.L., Medema, M.H. Artificial Intelligence for Natural Product Drug Discovery.<\/em> Nature Reviews Drug Discovery. 2023.https:\/\/www.nature.com\/articles\/s41573-023-00774-7<\/a><\/li>\n

    <\/p>\n

  6. Walker, A.S.<\/strong>, Clardy, J.\u00a0\u00a0A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters<\/em>. J. Chem. Inf. Model. 2021. 61<\/strong> (6). 2560-2571. https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.0c01304<\/a>
    (Featured as a supplemental cover)
    \"\"<\/li>\n

    <\/p>\n

    Preprints:<\/strong><\/p>\n

  7. Kalmer, T.L., Ancajas, C.M.F., Cohen, C.I., McDaniel, J.M., Oyedele, A.S., Thirman, H.L., Walker, A.S.<\/strong> Statistical Coupling Analysis Predicts Correlated Motions in Dihydrofolate Reductase.<\/em>https:\/\/doi.org\/10.1101\/2024.06.18.599103<\/a><\/li>\n

    <\/p>\n

  8. Biermann, F., Tan, B., Breitenbach, M., Nanudorn, P., Kakumu, Y., Dimitrova, Y., Walker, A.S.<\/strong>, Ueoka, R., Helfrich, E.J.N. Machine-learning based exploration, expansion and definition of the atropopeptide family of ribosomally synthesized and posttranslationally modified peptides.<\/em>https:\/\/www.biorxiv.org\/content\/10.1101\/2023.11.03.565440v1<\/a><\/li>\n

    <\/p>\n

    Other Independent Career Publications:<\/strong><\/p>\n

  9. You, C., Lee, S., Lee, J., Vuong, T., Lee, H. Jeong, S., Alishir, A., Walker, A.S.<\/strong>, Bae, G., Kim, K., Kang, J. Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism.<\/em> International Journal of Biological Sciences. 2023. 19 (15). 4898-4914.https:\/\/www.ijbs.com\/v19p4898.htm<\/a><\/li>\n

    <\/p>\n

    Other Publications Prior to Vanderbilt:<\/strong><\/p>\n

  10. Walker, A.S.<\/strong>, Russ, W.P., Ranganathan, R., Schepartz, A. RNA sectors and allosteric function within the ribosome<\/em>. Proc. Natl. Acad. Sci. U.S.A, 2020. 177 <\/strong>(33). 19879-19887.\u00a0https:\/\/www.pnas.org\/content\/117\/33\/19879.short<\/a><\/li>\n

    <\/p>\n

  11. Walker, A.S.<\/strong>, Pishchany, G., Clardy, J. Parsing Molecules for Drug Discovery<\/em>. Biochemistry, 2020. 59<\/strong> (17). 1645-1646.\u00a0https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.biochem.0c00278<\/a><\/li>\n

    <\/p>\n

  12. Reisberg, S.H., Gao, Y., Walker, A.S.<\/strong>, Helfrich, E.J.N., Clardy, J., Baran, P.S. Total synthesis reveals atypical atropisomerism in a small molecule Tryptorubin A.<\/em> Science, 2020. 367\u00a0<\/strong>(6476).\u00a0458-463.\u00a0https:\/\/science.sciencemag.org\/content\/367\/6476\/458.abstract<\/a><\/li>\n

    <\/p>\n

  13. Sinclair, J.K.L*., Walker, A.S.*<\/strong>, Doerner, A.E., Schepartz, A. Mechanism of information transfer into and through the plasma membrane by EGFR<\/em>. Cell Chem. Biol., 2018. 25<\/strong> (7). 857-870.\u00a0https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2451945618301193<\/a><\/li>\n

    <\/p>\n

  14. Walker, A.S.<\/strong>, Rablen, P.R., Schepartz, A., Rotamer-restricted fluorogenicity of the bis-arsenical ReAsH<\/em>. J. Am. Chem. Soc., 2016. 138<\/strong> (22). 7143-7150.\u00a0https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jacs.6b03422<\/a>
    (Featured in spotlights on recent JACS publications and the cover of the June 8, 2016 JACS issue)
    \"\"<\/li>\n

    <\/p>\n

  15. Melo Czekster, C., Robertson, W.E., Walker, A.S.<\/strong>, S\u00f6ll, D., Schepartz, A. In vivo<\/em> biosynthesis of a \u03b2-amino acid-containing protein. <\/em> J. Am. Chem. Soc., 2016. 138<\/strong> (16). 5194-5197.\u00a0https:\/\/pubs.acs.org\/doi\/full\/10.1021\/jacs.6b01023<\/a><\/li>\n

    <\/p>\n

  16. Melicher, M.S., Walker, A. S.<\/strong>, Shen, J. Miller, S.J., Schepartz, A. Improved carbohydrate recognition in water with an electrostatically enhanced \u03b2-peptide bundle<\/em>. Org. Lett., 2015. 17<\/strong> (19). 4718-4721.\u00a0https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.orglett.5b02187<\/a><\/li>\n

    <\/p>\n

  17. Melicher, M.S., Chu, J., Walker, A.S.<\/strong>, Miller, S.J., Baxter, R.H., Schepartz, A. A \u03b2-boronopeptide bundle of known structure as a vehicle for polyol recognition. <\/em> Org. Lett., 2013. 15 <\/strong>(19). 5048-5051.\u00a0https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ol402381n<\/a><\/li>\n

    <\/p>\n

  18. Hobert, E.M., Doerner, A.E., Walker A.S.<\/strong>, Schepartz, A. Effective molarity redux: proximity as a guiding force in chemistry and biology<\/em>. Isr. J. Chem. 2013. 53 <\/strong>(8). 567-576.\u00a0https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ijch.201300063<\/a><\/li>\n

    \n<\/ol>\n

    * = authors contributed equally<\/p>\n","protected":false},"excerpt":{"rendered":"

      Highlighted Publications: Ancajas, C.M.F, Oyedele, A., Butt, C., Walker, A.S., Advances, Opportunities, and Challenges in the Study of Structure Activity Relationships of Natural Products. 2024. Natural Product Reports. https:\/\/doi.org\/10.1039\/D4NP00009A Mabesoone, M.F.J., Leopold-Messer, S., Minas, H.A., Chepkirui, C., Chawengrum, P., Reiter, S., Meoded, R.A., Wolf, S., Genz, F., Magnus, N., Piechulla, B., Walker, A.S., Piel,…<\/p>\n","protected":false},"author":261,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-199","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/lab.vanderbilt.edu\/walker-lab\/wp-json\/wp\/v2\/pages\/199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.vanderbilt.edu\/walker-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.vanderbilt.edu\/walker-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/walker-lab\/wp-json\/wp\/v2\/users\/261"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/walker-lab\/wp-json\/wp\/v2\/comments?post=199"}],"version-history":[{"count":55,"href":"https:\/\/lab.vanderbilt.edu\/walker-lab\/wp-json\/wp\/v2\/pages\/199\/revisions"}],"predecessor-version":[{"id":377,"href":"https:\/\/lab.vanderbilt.edu\/walker-lab\/wp-json\/wp\/v2\/pages\/199\/revisions\/377"}],"wp:attachment":[{"href":"https:\/\/lab.vanderbilt.edu\/walker-lab\/wp-json\/wp\/v2\/media?parent=199"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/walker-lab\/wp-json\/wp\/v2\/tags?post=199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}