Skip to main content

Tyska Lab

Shaping the intestinal brush border.

AUTHORS

Crawley SWScott W , Mooseker MS Mark S , Tyska MJ Matthew J . The Journal of cell biology. 2014 11 24; 207(4). 441-451

ABSTRACT

Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract, remodel their apical surface during differentiation to form a brush border: an array of actin-supported membrane protrusions known as microvilli that increases the functional capacity of the tissue. Although our understanding of how epithelial cells assemble, stabilize, and organize apical microvilli is still developing, investigations of the biochemical and physical underpinnings of these processes suggest that cells coordinate cytoskeletal remodeling, membrane-cytoskeleton cross-linking, and extracellular adhesion to shape the apical brush border domain.