Ready…aim…fire into the lumen: a new role for enterocyte microvilli in gut host defense.
AUTHORS
Shifrin
DADavid A ,
Tyska
MJ Matthew J .
Gut microbes. 2012 ; 3(5).
460-2
- PMID: 22825496[PubMed].
- PMCID: PMC3466500.
ABSTRACT
Recent studies from our laboratory revealed that enterocyte brush border microvilli release small vesicles laden with host defense machinery into the intestinal lumen. In this addendum, we introduce a multi-faceted model for the function of these lumenal vesicles in the gut; we also consider some of the important unanswered questions that must be addressed in order to develop our understanding of this novel aspect of innate intestinal immunity.