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Publications

Independent

Under Review/In Preparation

20. Kelly M. Craft and Steven D. Townsend. Chemical Biology. IOBC. Invited Submission to the New Talent Issue. 2018. In Preparation.

19. Kelly M. Craft, Jennifer A. Gaddy and Steven D. Townsend. In Revision.

Published

18. Schuyler A. Chambers, Jenna M. DeSousa, Eric D. Huseman, and Steven D. Townsend*. The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production. ACS Chem. Neurosci. 2018. DOI: 10.1021/acschemneuro.7b00528

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  • Invited submission

17. Dorothy L. Ackerman,# Kelly M. Craft,# Ryan S. Doster, Jörn-Hendrik Weitkamp, David M. Aronoff, Jennifer A. Gaddy, and Steven D. Townsend*. Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides Against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumanniiACS Infect. Dis. 2018. DOI: 10.1021/acsinfecdis.7b00183 Extended Scope Graphical Abstract copy

  • # equal contribution
  • Most read article for December 2017!

16. Kelly M. Craft and Steven D. Townsend*.  The Human Milk Glycome as a Defense Against Infectious Diseases.  ACS Infect. Dis. 2018. DOI: 10.1021/acsinfecdis.7b00209

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15. Yong Guan and Steven D. Townsend*.  Metal-Free Synthesis of Unsymmetrical Organoselenides and Selenoglycosides.  Org. Lett. 2017, 19, 5252-5255. DOI: 10.1021/acs.orglett.7b02526

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14.  D. Jamin Keith, Stefan A. Marasligiller,# Alexander W. Sasse,# and Steven D. Townsend*.  One-Pot, Microwave-Assisted Conversion of Anomeric Nitrate-Esters. to Trichloroacetimidates. J. Vis. Exp. 2017. In Press.

  • Invited submission
  • # = undergraduate co-authors

13. Dorothy L. Ackerman, Ryan S. Doster, Jörn-Hendrik Weitkamp, David M. Aronoff, Jennifer A. Gaddy, and Steven D. Townsend*.  Human Milk Oligosaccharides Exhibit Antimicrobial and Anti-Biofilm Properties Against Group B Streptococcus.  ACS Infect. Dis. 2017, 3, 595-605. DOI: 10.1021/acsinfecdis.7b00064

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12.  D. Jamin Keith and Steven D. Townsend*.  Direct, Microwave-Assisted Substitution of Anomeric Nitrate-Esters. Carbohydr. Res. 2017, 442, 20-24.

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11.  Kelly M. Craft and Steven D. Townsend*.  Synthesis of Lacto-N-Tetraose. Carbohydr. Res. 2017, 440-441, 43-50.

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10.  Dorothy L. Ackerman, Kelly M. Craft, and Steven D. Townsend*.  Infant Food Applications of Complex Carbohydrates:  Structure, Synthesis, and Function.  Carbohydr. Res. 2017, 437, 16-27.

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Mentored

9.  Steven D. Townsend, Audrey G. Ross, Kai Liu, and Samuel J. Danishefsky*.  Stereospecific Cis and Trans Ring Fusions Arising From Common Intermediates.  Proc. Natl. Acad. Sci. U.S.A. 2014, 111(22), 7931-7935.

8.  Steven D. Townsend and Gary A. Sulikowski*.  Progress toward the Total Synthesis of Bielschowskysin.  Org. Lett. 2013, 15(19), 5096-5098.

7.  Audrey G. Ross, Steven D. Townsend, and Samuel J. Danishefsky*.  Halocycloalkenones as Diels-Alder Dienophiles.  Applications to Generating Useful Structural Patterns.  J. Org. Chem. 2013, 78(1), 204-210. Invited submission for the Robert Ireland Memorial Issue.

6.  Jianfeng Li, Suwei Dong, Steven D. Townsend, Thomas Dean, Thomas J. Gardella, and Samuel J. Danishefsky*.  Chemistry as an Expanding Resource in Protein Science.  Fully Synthetic and Fully Active Human Parathyroid Hormone-Related Protein (1-141). Angew. Chem. Int. Ed. 2012, 51(49), 12263-12267.

5.  Ping Wang, Suwei Dong, John A. Brailsford, Karthik Iyer, Steven D. Townsend, Qiang Zhang, Ronald Henderickson, JaeHung Shieh, Malcolm A. S. Moore, and Samuel J. Danishefsky*.  At Last: Erythropoietin as a Single Glycoform. Angew. Chem. Int. Ed. 2012, 51(46), 11576-11584.

4.  Steven D. Townsend, Xiangyang Wu, and Samuel J. Danishefsky*.  Enhancing the Scope of the Diels-Alder Reaction through Isonitrile Chemistry: Emergence of a New Class of Acyl Activated Dienophiles. J. Am. Chem. Soc. 2012, 134(25), 10659-10663.

3.  Steven D. Townsend, Zhongping Tan, Suwei Dong, Shiying Shang, John A. Brailsford, and Samuel J. Danishefsky*.  Advances in Proline Ligation.  J. Am. Chem. Soc. 2012, 134(8), 3912-3916.

2.  Haibo Yu, Meng Wu, Steven D. Townsend, Beiyan Zou, Shunyou Long, J. Scott Daniels, Owen B. McManus, Min Li, Craig W. Lindsley, and Corey R. Hopkins*.  Discovery, Synthesis, and Structure–Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides:   Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener. ACS Chem. Neurosci. 2011, 2(10), 572–577.

1.  Alexis S. Hammond, Alice L. Rodriguez, Steven D. Townsend, Colleen M. Niswender, Karen J. Gregory, Craig W. Lindsley, and P. Jeffrey Conn*. Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chem. Neurosci. 2010, 1(10), 702–716.

NIH Molecular Libraries Program Probe Reports
1. Yu, H.; Wu, M.; Hopkins, C. R.; Engers, J.; Townsend, S.; Lindsley, C.; McManus, O.B.; Li, M. A small molecule activator of KCNQ2 and KCNQ4 channels, 2011, Bookshelf ID: NBK121449.PMID: 23658954