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Identification of a naturally occurring peroxidase-lipoxygenase fusion protein.


Koljak| Boutaud| Shieh| Samel| Brash R| O| BH| N| ARR| O| B H| N| A R . Science (New York, N.Y.). 1997 9 26; 277(5334). 1994-6


A distant relative of catalase that is specialized for metabolism of a fatty acid hydroperoxide was identified. This heme peroxidase occurs in coral as part of a fusion protein, the other component of which is a lipoxygenase that forms the hydroperoxide substrate. The end product is an unstable epoxide (an allene oxide) that is a potential precursor of prostaglandin-like molecules. These results extend the known chemistry of catalase-like proteins and reveal a distinct type of enzymatic construct involved in the metabolism of polyunsaturated fatty acids.

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