{"id":96,"date":"2018-06-19T13:20:51","date_gmt":"2018-06-19T13:20:51","guid":{"rendered":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/publications\/"},"modified":"2026-06-19T03:50:52","modified_gmt":"2026-06-19T03:50:52","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<h2>Info Text &#8211; Right Hand Column Placeholder<br \/>Refresh After Saving to Remove<\/h2>\n  <h3><strong>Contact Us<\/strong><\/h3>\n<p>The O&#8217;Brien Lab is located in room 8415 MRB IV<\/p>\n<p><strong>Lab Phone<\/strong><\/p>\n<p><a href=\"tel:(615) 936-1629\">(615) 936-1629<\/a><\/p>\n<p><strong>Office Phone <\/strong><\/p>\n<p><a href=\"tel:(615) 936-1503\">(615) 936-1503<\/a><\/p>\n<p><strong>Mailing Address<\/strong><\/p>\nDepartment of Molecular Physiology &amp; Biophysics<br \/>\n8415 MRB IV<br \/>\n2213 Garland Avenue<br \/>\nVanderbilt University School of Medicine<br \/>\nNashville, TN 37232-0615\n        <p>Selected Published Works<\/p>\n<ul>\n<li>Overway, E.M., Bosma, K.J., Claxton, D.P., Oeser, J.K., Singh, K., Breidenbach, L.B., Mchaourab, H.S., Davis, L.K. and O&#8217;Brien, R.M. Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose. J. Biol. Chem., 298, 101534, 2022.<\/li>\n<li>Claxton, D.P., Overway, E.M., Oeser, J.K., O&#8217;Brien, R.M. and Mchaourab, H.S. Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1. J. Biol. Chem., 298, 101520, 2022.<\/li>\n<li>Bosma, K.J., Rahim, M, Oeser, J.K., McGuinness, O.P., Young, J.D. and O&#8217;Brien, R.M. G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting. Mol. Metab. 41, 101043, 2020.<\/li>\n<li>Syring, K.E., Bosma, K.J., Goleva, S.B., Singh, K., Oeser, J.K., Lopez, C.A., Skaar, E.P., McGuinness, O.P., Davis, L.K., Powell,. D.R. and O&#8217;Brien, R.M. Potential positive and negative consequences of ZnT8 inhibition. Jour. of Endocrinol., 246, 189-205, 2020.<\/li>\n<li>Mosleh, E., Ou, K., Haemmerle, M.W., Tembo, T., Yuhas, A., Carboneau, B.A., Townsend, S.E., Bosma, K.J., Gannon, M., O&#8217;Brien, R.M., Stoffers, D.A. and Golson, M.L. Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation. Endocrinology, 161, 2020.<\/li>\n<li>Bosma, K.J., Rahim, M., Singh, K., Goleva, S.B., Wall, M.L., Xia, J., Syring, K.E., Oeser, J.K., Poffenberger, G., McGuinness, O.P., Means, A.L., Powers, A.C., Li, W., Davis, L.K., Young, J.D. and O&#8217;Brien, R.M. Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose. Jour. of Mol. Endocrinol., 64, 235-248, 2020.<\/li>\n<li>Bosma, K.J., Syring, K.E., Oeser, J.K., Lee, J.D., Benninger, R.KP., Pamenter, M.E., and O&#8217;Brien, R.M. Evidence that evolution of the diabetes susceptibility gene SLC30A8 that encodes the zinc transporter ZnT8 drives variations in pancreatic islet zinc content in multiple species. Jour. of Mol. Evolution, 87, 147-151, 2019.<\/li>\n<li>Syring, K.E., Bosma, K.J., Oeser, J.K., Shiota, M., and O&#8217;Brien, R.M. The diabetes susceptibility gene SLC30A8 that encodes the zinc transporter ZnT8 is a pseudogene in guinea pigs potentially contributing to low guinea pig islet zinc content. Jour. of Mol. Evolution, 86, 613-617, 2018.<\/li>\n<\/ul>\n<p>A full list of publications can be found <a href=\"https:\/\/scholar.google.com\/citations?hl=en&amp;user=SpOZQc4AAAAJ\">here<\/a><\/p>\n <!-- rich-text -->\n\n","protected":false},"excerpt":{"rendered":"<p>Info Text &#8211; Right Hand Column PlaceholderRefresh After Saving to Remove Contact Us The O&#8217;Brien Lab is located in room 8415 MRB IV Lab Phone (615) 936-1629 Office Phone (615) 936-1503 Mailing Address Department of Molecular Physiology &amp; Biophysics 8415 MRB IV 2213 Garland Avenue Vanderbilt University School of Medicine Nashville, TN 37232-0615 Selected Published [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-96","page","type-page","status-publish","hentry"],"acf":[],"ACF":{"topper_style":"default","topper_overline":"","topper_title":"","topper_intro":"","default_topper_background_type":"none","footer_style":"standard","recirculation_style":"none","nav_menu":"","nav_menu_secondary":"no","page_style_option":"details","page_theme_option":"light","page_class_name":"","page_jumplinks_option":"no"},"_links":{"self":[{"href":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/wp-json\/wp\/v2\/pages\/96","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/wp-json\/wp\/v2\/comments?post=96"}],"version-history":[{"count":9,"href":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/wp-json\/wp\/v2\/pages\/96\/revisions"}],"predecessor-version":[{"id":480,"href":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/wp-json\/wp\/v2\/pages\/96\/revisions\/480"}],"wp:attachment":[{"href":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/wp-json\/wp\/v2\/media?parent=96"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/richard-obrien-lab\/wp-json\/wp\/v2\/tags?post=96"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}