{"id":92,"date":"2018-06-19T14:43:33","date_gmt":"2018-06-19T14:43:33","guid":{"rendered":"https:\/\/lab.vanderbilt.edu\/patton-lab\/research-interests\/"},"modified":"2026-10-19T15:18:41","modified_gmt":"2026-10-19T15:18:41","slug":"research-interests","status":"publish","type":"page","link":"https:\/\/lab.vanderbilt.edu\/patton-lab\/research-interests\/","title":{"rendered":"Research Interests"},"content":{"rendered":"\n\n          <h2>Biogenesis and function of extracellular RNAs in cancer<\/h2>\n        <p>There is increasing evidence that in cancer the secretion of extracellular vesicles, such as exosomes, can manipulate the local and systemic environment to enhance tumor growth and dissemination. Several studies have shown that exosomes contain distinct cargo, including microRNAs (miRNAs), and that they are involved in intercellular communication. An outstanding question regarding extracellular RNAs is whether their export from cells is specific and actively regulated; and if so, how this selection process occurs. Additionally, little is understood about the exact function of extracellular miRNAs and how they pertain to health and disease. Using colon cancer cell lines, we are interested in understanding the biogenesis and function of exosomal miRNAs, the molecular pathway(s) by which miRNAs are sorted to exosomes, and ultimately, how these processes are deregulated during oncogenesis.<\/p>\n <!-- rich-text -->\n\n","protected":false},"excerpt":{"rendered":"<p>Biogenesis and function of extracellular RNAs in cancer There is increasing evidence that in cancer the secretion of extracellular vesicles, such as exosomes, can manipulate the local and systemic environment to enhance tumor growth and dissemination. Several studies have shown that exosomes contain distinct cargo, including microRNAs (miRNAs), and that they are involved in intercellular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-92","page","type-page","status-publish","hentry"],"acf":[],"ACF":{"topper_style":"default","topper_overline":"","topper_title":"","topper_intro":"","default_topper_background_type":"none","footer_style":"standard","recirculation_style":"none","nav_menu":"","nav_menu_secondary":"no","page_style_option":"details","page_theme_option":"light","page_class_name":"","page_jumplinks_option":"no"},"_links":{"self":[{"href":"https:\/\/lab.vanderbilt.edu\/patton-lab\/wp-json\/wp\/v2\/pages\/92","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.vanderbilt.edu\/patton-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.vanderbilt.edu\/patton-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/patton-lab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/patton-lab\/wp-json\/wp\/v2\/comments?post=92"}],"version-history":[{"count":7,"href":"https:\/\/lab.vanderbilt.edu\/patton-lab\/wp-json\/wp\/v2\/pages\/92\/revisions"}],"predecessor-version":[{"id":616,"href":"https:\/\/lab.vanderbilt.edu\/patton-lab\/wp-json\/wp\/v2\/pages\/92\/revisions\/616"}],"wp:attachment":[{"href":"https:\/\/lab.vanderbilt.edu\/patton-lab\/wp-json\/wp\/v2\/media?parent=92"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/patton-lab\/wp-json\/wp\/v2\/tags?post=92"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}