Congratulations to Dr. James O’Connor on his thesis defense!
Feb. 8, 2022—On Friday, January 28, 2022, James O’Connor presented his work titled, “A Protease-initiated Model of Wound Detection.” He gave an excellent presentation, and everyone loved his movies. His committee comprised of Dr. Matthew Tyska, Dr. Ian Macara, Dr. Jared Nordman, and Dr. M. Shane Hutson, approved his thesis with no corrections! Congratulations, Dr. O’Connor!
A review article in the Journal of Cell Science
Feb. 8, 2022—Indrayani published a review in the Journal of Cell Science summarizing glypican-mediated Wnt distribution. In this review, we summarize, critique, and provide revisions to all the reported models of Wnt distribution. We especially focus on glypican-mediated mechanisms, which primarily establish Wnt gradients in vivo. An up-to-date summary of seminal studies on how glypicans spread extracellular Wnts...
Indrayani recieved a K99!
Jan. 9, 2022—Indrayani received a K99 award from the NIGMS to study mechanisms of Wg/Wnt regulation by glypican Dlp (01/22-12/23). The award funds research where she will integrate the Drosophila genetic tools with biochemical, proteomic, and imaging approaches to investigate how Dlp-mediated regulation of Wnt signaling is affected by proteolytic cleavage of Dlp my Matrix Metalloprotease2 (Mmp2) in developmental...
Kimi had a baby!
Jan. 8, 2022—Congratulations to Kimi and Zach as they welcomed Sophie on December 4th, 2021! Everyone is doing well!
A new paper in PLoS One
Jan. 8, 2022—James O’Connor et al published a new paper in PLoS One! This work characterized several different types of cellular damage within a wounded epithelial tissue, allowing for distinct regions of damage to be estimated after measuring any one type of damage.
James O’Connor wins Steve Hann CDB Outstanding Graduate Student Award!
Jan. 6, 2022—James O’Connor won the Steve Hann CDB Outstanding Graduate Student Award at the 2021 CDB retreat on October 22nd. The CDB outstanding grad student award is “given annually in recognition of outstanding research achievements by a graduate student” and is named for the late Steve Hann, a former DGS of CDB. Congratulations James!
2021 Awards
Sep. 13, 2021—Congratulations to the members of the Page-McCaw Lab who have been recognized this year! 2021 Program in Developmental Biology Retreat James O’Connor: Best Poster (graduate student) James White: Best Talk (graduate student) Elkie Peebles: Best Poster (research assistant) Indrayani: Best Poster (post-doc) 2021 American Society for Matrix Biology Meeting Aubrie Stricker: Travel Award and Flash...
Congratulations to Aubrie for passing her Qualifying Exam!
Jul. 23, 2021—Congrats to Aubrie for passing her qualifying exam!
A new paper in Developmental Cell!
Jul. 22, 2021—James O’Connor et al has published a new paper in Developmental Cell. The highlights of this paper include: Wounds induce a rapid increase in cytosolic calcium in cells around the wound The GPCR Mthl10 and its cytokine ligands Gbp1 and Gbp2 are required for this process Wound-induced proteases initiate the process by activating the cytokine...
A new paper in PLOS Genetics!
May. 28, 2021—We (and others) previously observed that the secreted Wingless ligand spreads extracellularly in the fly ovary, ~50 µm away from the cells that secrete it, and when we compromised the Wg gradient by altering Dlp levels, egg formation was disrupted. However, it has also been proposed that Wg does not spread, but rather signals in...