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A new paper in Developmental Cell!

Posted by on Thursday, July 22, 2021 in Lab News.

James O’Connor et al has published a new paper in Developmental Cell. The highlights of this paper include:

  • Wounds induce a rapid increase in cytosolic calcium in cells around the wound
  • The GPCR Mthl10 and its cytokine ligands Gbp1 and Gbp2 are required for this process
  • Wound-induced proteases initiate the process by activating the cytokine proligands
  • Computational modeling validates these steps as a mechanism for rapid wound detection

Congrats to everyone involved!