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Nakagawa Lab

Neurobiology. A stargazer foretells the way to the synapse.

AUTHORS

Nakagawa TT , Sheng M M . Science (New York, N.Y.). 2000 12 22; 290(5500). 2270-1

ABSTRACT

How do AMPA receptors that are made in the cytoplasm of excitatory neurons travel to and become localized in the distant postsynaptic membranes of dendrites? Nakagawa and Sheng, in a Perspective, suggest that the answer may lie in the stargazin protein that has now been found to interact with AMPA receptors, guiding them to the postsynaptic membrane.