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Nakagawa Lab

Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.

AUTHORS

Setou MM , Nakagawa T T , Seog DH D H , Hirokawa N N . Science (New York, N.Y.). 2000 6 9; 288(5472). 1796-802

ABSTRACT

Experiments with vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites. Selective transport is accomplished by direct interaction of the KIF17 tail with a PDZ domain of mLin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis), and the NR2B subunit. This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis.