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Spatial localization of A2E in the retinal pigment epithelium.


Grey| Crouch| Koutalos| Schey| Ablonczy AC| RK| Y| KL| ZAngus C| Rosalie K| Yiannis| Kevin L| Zsolt . Investigative ophthalmology & visual science. 2011 6 ; 52(7). 3926-33


Lipofuscin, a fluorescent lysosomal pigment made of lipophilic molecules, is associated with age-related pathophysiological processes in the retinal pigment epithelium (RPE). The best-characterized components of lipofuscin are A2E and its oxides, but a direct spatial correlation with lipofuscin has not previously been possible.

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