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Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium.


Ablonczy| Higbee| Anderson| Dahrouj| Grey| Gutierrez| Koutalos| Schey| Hanneken| Crouch Z| D| DM| M| AC| D| Y| KL| A| RKZsolt| Daniel| David M| Mohammad| Angus C| Danielle| Yiannis| Kevin L| Anne| Rosalie K . Investigative ophthalmology & visual science. 2013 8 ; 54(8). 5535-42


The accumulation of lipofuscin in the RPE is a hallmark of aging in the eye. The best characterized component of lipofuscin is A2E, a bis-retinoid byproduct of the normal retinoid visual cycle, which exhibits a broad spectrum of cytotoxic effects in vitro. The purpose of our study was to correlate the distribution of lipofuscin and A2E across the human RPE.

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