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Mechanobiology

Matrix stiffness primes cells for future oxidative stress

AUTHORS

Taufalele PVPaul V , Reinhart-King CACynthia A . Trends in cancer. 2021 8 18; 7(10). 883-885

ABSTRACT

Focus on metabolic reprogramming has re-emerged in recent years due to the far-reaching consequences of metabolism on nearly all cellular behaviors. In a recent study in Cell Metabolism, Tharp et al. show that adhesion-dependent mechanical signaling induces mitochondrial and metabolic reprogramming to help cells adapt to future oxidative stress.