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Mechanobiology

Directed migration: Cells navigate by extracellular vesicles

AUTHORS

Sung BHBong Hwan , Weaver AMAlissa M . The Journal of cell biology. 2018 7 5; 217(8). 2613-2614

ABSTRACT

Directional cell motility toward a chemical gradient, chemotaxis, is critical during inflammation, embryogenesis, and cancer metastasis. In this issue, Kriebel et al. (2018. https://doi.org/10.1083/jcb.201710170) demonstrate that the key cAMP chemoattractant for amoebas is synthesized within and released from extracellular vesicles to promote chemotaxis.