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Marnett Research Laboratory

Marnett Research Laboratory Publications

2024

Aleem M , Mitchener M , Kingsley J , Rouzer A , Marnett J , Temporal dissociation of COX-2-dependent arachidonic acid and 2-arachidonoylglycerol metabolism in RAW264.7 macrophages 2024 Aug 5;

2023

Uddin MJ , Niitsu H , Coffey RJ , Marnett LJ , Development of Pluoronic nanoparticles of fluorocoxib A for endoscopic fluorescence imaging of colonic adenomas Journal of biomedical optics. 2023 Apr 20; 28 (4). 040501
Morrison VE , Houpert MG , Trapani JB , Brockman AA , Kingsley PJ , Katdare KA , Layden HM , Nguena-Jones G , Trevisan AJ , Maguire-Zeiss KA , Marnett LJ , Bixa GJ , Ihrie RA , Carter BD , Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone bioRxiv : the preprint server for biology. 2023 Mar 6;
Aleem AM , Kang W , Lin S , Milad M , Kingsley PJ , Crews BC , Uddin MJ , Rouzer CA , Marnett LJ , Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages ACS chemical biology. 2023 Jan 13;

2022

Uddin MJ , Lo JH , Oltman CG , Crews BC , Huda T , Liu J , Kingsley PJ , Lin S , Milad M , Aleem AM , Asaduzzaman A , McIntyre JO , Duvall CL , Marnett LJ , Discovery of a Redox-Activatable Chemical Probe for Detection of Cyclooxygenase-2 in Cells and Animals ACS chemical biology. 2022 Jul 5;
Haney M , Bedi G , Cooper ZD , Herrmann ES , Reed SC , Foltin RW , Kingsley PJ , Marnett LJ , Patel S , Impact of cyclooxygenase-2 inhibition on cannabis withdrawal and circulating endocannabinoids in daily cannabis smokers Addiction biology. 2022 Jul 2; 27 (4). e13183
Hu M , Zhu D , Zhang J , Gao F , Hashem J , Kingsley P , Marnett LJ , Mackie K , Chen C , Enhancing endocannabinoid signalling in astrocytes promotes recovery from traumatic brain injury Brain : a journal of neurology. 2022 Mar 11; 145 (1). 179-193
Zimmermann A , Vu O , Brüser A , Sliwoski G , Marnett LJ , Meiler J , Schöneberg T , Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y ChemMedChem. 2022 Jan 28; 17 (7). e202100683
Smalling RV , Bechard ME , Duryea J , Kingsley PJ , Roberts ER , Marnett LJ , Bilbao D , Stauffer SR , McDonald OG , Aminopyridine analogs selectively target metastatic pancreatic cancer Oncogene. 2022 Jan 14; 41 (10). 1518-1525

2021

Christov PP , Richie-Jannetta R , Kingsley PJ , Vemulapalli A , Kim K , Sulikowski GA , Rizzo CJ , Ketkar A , Eoff RL , Rouzer CA , Marnett LJ , Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-MdG, the Genomic Metabolite of MdG, and Liquid Chromatography-Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι Chemical research in toxicology. 2021 Dec 3;
Farrell JS , Colangeli R , Dong A , George AG , Addo-Osafo K , Kingsley PJ , Morena M , Wolff MD , Dudok B , He K , Patrick TA , Sharkey KA , Patel S , Marnett LJ , Hill MN , Li Y , Teskey GC , Soltesz I , In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity Neuron. 2021 Aug 21; 109 (15). 2398-2403.e4
Winters ND , Bedse G , Astafyev AA , Patrick TA , Altemus M , Morgan AJ , Mukerjee S , Johnson KD , Mahajan VR , Uddin MJ , Kingsley PJ , Centanni SW , Siciliano CA , Samuels DC , Marnett LJ , Winder DG , Patel S , Targeting diacylglycerol lipase reduces alcohol consumption in preclinical models The Journal of clinical investigation. 2021 Jul 22;

2020

Reyes-Uribe L , Wu W , Gelincik O , Bommi PV , Francisco-Cruz A , Solis LM , Lynch PM , Lim R , Stoffel EM , Kanth P , Samadder NJ , Mork ME , Taggart MW , Milne GL , Marnett LJ , Vornik L , Liu DD , Revuelta M , Chang K , You YN , Kopelovich L , Wistuba II , Lee JJ , Sei S , Shoemaker RH , Szabo E , Richmond E , Umar A , Perloff M , Brown PH , Lipkin SM , Vilar E , Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa Gut. 2020 Jul 08;
Cekanova M , Pandey S , Olin S , Ryan P , Stokes JE , Hecht S , Martin-Jimenez T , Uddin MJ , Marnett LJ , Pharmacokinetic characterization of fluorocoxib D, a cyclooxygenase-2-targeted optical imaging agent for detection of cancer Journal of biomedical optics. 2020 Aug 10; 25 (8).
Rouzer CA , Marnett LJ , Structural and Chemical Biology of the Interaction of Cyclooxygenase with Substrates and Non-Steroidal Anti-Inflammatory Drugs Chemical reviews. 2020 Jul 1;
Uddin MJ , Vemulapalli A , Niitsu H , Crews BC , Oltman CG , Kingsley PJ , Kavanaugh TE , Bedingfield SK , Mcintyre JO , Milad M , Aleem AM , Coffey RJ , Duvall CL , Marnett LJ , Molecular Imaging of Inflammation in Osteoarthritis Using a Water-Soluble Fluorocoxib ACS medicinal chemistry letters. 2020 Feb 24; 11 (10). 1875-1880
Uddin MJ , Xu S , Crews BC , Aleem AM , Ghebreselasie K , Banerjee S , Marnett LJ , Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors ACS medicinal chemistry letters. 2020 Feb 14; 11 (10). 1881-1885

2019

Malerba P , Crews BC , Ghebreselasie K , Daniel CK , Jashim E , Aleem AM , Salam RA , Marnett LJ , Uddin MJ , Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer ACS medicinal chemistry letters. 2019 Jul 24; 11 (10). 1837-1842
Kingsley PJ , Rouzer CA , Morgan AJ , Patel S , Marnett LJ , Aspects of Prostaglandin Glycerol Ester Biology Advances in experimental medicine and biology. 2019 Sep 28; 1161 77-88
Marnett LJ , Adventures with Bruce Ames and the Ames test Mutation research. 2019 Jul 4; 846 403070
Chopra S , Giovanelli P , Alvarado-Vazquez PA , Alonso S , Song M , Sandoval TA , Chae CS , Tan C , Fonseca MM , Gutierrez S , Jimenez L , Subbaramaiah K , Iwawaki T , Kingsley PJ , Marnett LJ , Kossenkov AV , Crespo MS , Dannenberg AJ , Glimcher LH , Romero-Sandoval EA , Cubillos-Ruiz JR , IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain Science (New York, N.Y.). 2019 Jul 19; 365 (6450).
Shockley EM , Rouzer CA , Marnett LJ , Deeds EJ , Lopez CF , Signal integration and information transfer in an allosterically regulated network NPJ systems biology and applications. 2019 Jul 18; 5 23
Scilimati A , Ferorelli S , Iaselli MC , Miciaccia M , Pati ML , Fortuna CG , Aleem AM , Marnett LJ , Perrone MG , Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection European journal of medicinal chemistry. 2019 Jun 15; 179 16-25
Uddin MJ , Wilson AJ , Crews BC , Malerba P , Uddin MI , Kingsley PJ , Ghebreselasie K , Daniel CK , Nickels ML , Tantawy MN , Jashim E , Manning HC , Khabele D , Marnett LJ , Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer ACS omega. 2019 May 24; 4 (5). 9251-9261
Xu S , Uddin MJ , Banerjee S , Duggan K , Musee J , Kiefer JR , Ghebreselasie K , Rouzer CA , Marnett LJ , Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site The Journal of biological chemistry. 2019 Apr 18; 294 (22). 8690-8698

2018

Wepy JA , Galligan JJ , Kingsley PJ , Xu S , Goodman MC , Tallman KA , Rouzer CA , Marnett LJ , Lysophospholipases Cooperate to Mediate Lipid Homeostasis and Lysophospholipid Signaling Journal of lipid research. 2018 Nov 27;
Liu Y , Ji L , Eno M , Kudalkar S , Li AL , Schimpgen M , Benchama O , Morales P , Xu S , Hurst D , Wu S , Mohammad KA , Wood JT , Zvonok N , Papahatjis DP , Zhou H , Honrao C , Mackie K , Reggio P , Hohmann AG , Marnett LJ , Makriyannis A , Nikas SP , ( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes Journal of medicinal chemistry. 2018 Sep 21; 61 (19). 8639-8657
Galligan JJ , Wepy JA , Streeter MD , Kingsley PJ , Mitchener MM , Wauchope OR , Beavers WN , Rose KL , Wang T , Spiegel DA , Marnett LJ , Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 27;
Cavener VS , Gaulden A , Pennipede D , Jagasia P , Uddin J , Marnett LJ , Patel S , Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice Frontiers in neuroscience. 2018 Jul 31; 12 479
Morgan AJ , Kingsley PJ , Mitchener MM , Altemus M , Patrick TA , Gaulden AD , Marnett LJ , Patel S , Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain ACS Chemical Neuroscience. 2018 May 9;
Bedse G , Bluet RJ , Patrick TA , Romness KN , Gaulden AD , Kingsley PJ , Plath N , Marnett LJ , Patel S , Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors Translational Psychiatry. 2018 Apr 26; 8 (1).
Wauchope OR , Mitchener MM , Beavers WN , Galligan JJ , Camarillo JM , Sanders WD , Kingsley PJ , Shim HN , Blackwell T , Luong T , deCaestecker M , Fessel JP , Marnett LJ , Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA Nucleic acids research. 2018 Apr 20; 46 (7). 3458-3467
Goodman MC , Xu S , Rouzer CA , Banerjee S , Ghebreselasie K , Migliore M , Piomelli D , Marnett LJ , Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the … The Journal of biological chemistry. 2018 Jan 11;
Beeghly-Fadiel A , Wilson AJ , Keene S , El Ramahi M , Xu S , Marnett LJ , Fadare O , Crispens MA , Khabele D , Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors Journal of Ovarian Research. 2018 Feb 27; 17 (11 (1)).

2017

Bedse G , Hartley ND , Neale E , Gaulden AD , Patrick TA , Kingsley PJ , Uddin MJ , Plath N , Marnett LJ , Patel S , Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxie… Biological psychiatry. 2017 Mar 15;
Pulley JM , Shirey-Rice JK , Lavieri RR , Jerome RN , Zaleski NM , Aronoff DM , Bastarache L , Niu X , Holroyd KJ , Roden DM , Skaar EP , Niswender CM , Marnett LJ , Lindsley CW , Ekstrom LB , Bentley AR , Bernard GR , Hong CC , Denny JC , Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay and drug development technologies. 2017 Apr ; 15 (3). 113-119
Bluett RJ , Báldi R , Haymer A , Gaulden AD , Hartley ND , Parrish WP , Baechle J , Marcus DJ , Mardam-Bey R , Shonesy BC , Uddin MJ , Marnett LJ , Mackie K , Colbran RJ , Winder DG , Patel S , Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. Nature communications. 2017 Mar 28; 8 14782
Aldrovandi M , Hinz C , Lauder SN , Podmore H , Hornshaw M , Slatter DA , Tyrrell VJ , Clark SR , Marnett LJ , Collins PW , Murphy RC , O'Donnell VB , DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil inte… Redox biology. 2017 Apr ; 11 663-672
Galligan JJ , Kingsley PJ , Wauchope OR , Mitchener MM , Camarillo JM , Wepy JA , Harris PS , Fritz KS , Marnett LJ , Quantitative Analysis and Discovery of Lysine and Arginine Modifications. Analytical chemistry. 2017 Jan 17; 89 (2). 1299-1306
Camarillo JM , Ullery JC , Rose KL , Marnett LJ , Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Lin… Chemical research in toxicology. 2017 Feb 20; 30 (2). 635-641
Galligan JJ , Marnett LJ , Histone Adduction and Its Functional Impact on Epigenetics. Chemical research in toxicology. 2017 Dec 17; 30 (1). 376-387
Beavers WN , Rose KL , Galligan JJ , Mitchener MM , Rouzer CA , Tallman KA , Lamberson CR , Wang X , Hill S , Ivanova PT , Brown HA , Zhang B , Porter NA , Marnett LJ , Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and T… ACS chemical biology. 2017 Jun 28;
Brüser A , Zimmermann A , Crews BC , Sliwoski G , Meiler J , König GM , Kostenis E , Lede V , Marnett LJ , Schöneberg T , Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6. Scientific reports. 2017 May 24; 7 (1). 2380

2016

Konkle ME , Blobaum AL , Moth CW , Prusakiewicz JJ , Xu S , Ghebreselasie K , Akingbade D , Jacobs AT , Rouzer CA , Lybrand TP , Marnett LJ , Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Ami… Biochemistry. 2016 Jan 19; 55 (2). 348-59
Camarillo JM , Rose KL , Galligan JJ , Xu S , Marnett LJ , Covalent modification of CDK2 by 4-hydroxynonenal as a mechanism of inhibition of cell cycle progres… Chemical Research in Toxicology. 2016 Feb 24;
Gamble-George JC , Baldi R , Halladay L , Kocharian A , Hartley N , Silva CG , Roberts H , Haymer A , Marnett LJ , Holmes A , Patel S , Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. eLife. 2016 ; 5
Hinz C , Aldrovandi M , Uhlson C , Marnett LJ , Longhurst HJ , Warner TD , Alam S , Slatter DA , Lauder SN , Allen-Redpath K , Collins PW , Murphy RC , Thomas CP , O'Donnell VB , Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid… The Journal of Biological Chemistry. 2016 Apr 22;
Mont S , Davies SS , Roberts Second LJ , Mernaugh RL , McDonald WH , Segal BH , Zackert W , Kropski JA , Blackwell TS , Sekhar KR , Galligan JJ , Massion PP , Marnett LJ , Travis EL , Freeman ML , Accumulation of isolevuglandin-modified protein in normal and fibrotic lung. Scientific reports. 2016 ; 6 24919
Uddin MJ , Werfel TA , Crews BC , Gupta MK , Kavanaugh TE , Kingsley PJ , Boyd K , Marnett LJ , Duvall CL , Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation… Biomaterials. 2016 Jun ; 92 71-80
Cook PJ , Thomas R , Kingsley PJ , Shimizu F , Montrose DC , Marnett LJ , Tabar VS , Dannenberg AJ , Benezra R , Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental gliob… Neuro-oncology. 2016 Mar ;
Kudalkar SN , Kingsley PJ , Marnett LJ , Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. Methods in molecular biology (Clifton, N.J.). 2016 ; 1412 205-15
Adeniji A , Uddin MJ , Zang T , Tamae D , Wangtrakuldee P , Marnett LJ , Penning TM , , Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reduc… Journal of Medicinal Chemistry. 2016 Aug ; 16 (59). 7431-7444
Uddin MJ , Crews BC , Ghebreselasie K , Daniel CK , Kingsley PJ , Banerjee S , Marnett LJ , Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors ACS Chemical Biology. 2016 Sep 19;
Uddin MJ , Moore CE , Crews BC , Daniel CK , Ghebreselasie Kathleen L , McIntyre JO , Marnett LJ , Jayagopal A , Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovasculari… Journal of Biomedical Optics. 2016 Sep 1; 21 (9).
Boutaud O , Sosa IR , Amin T , Oram D , Adler D , Hwang HS , Crews BC , Milne G , Harris BK , Hoeksema M , Knollmann BC , Lammers PE , Marnett LJ , Massion PP , Oates JA , Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcin… Cancer prevention research (Philadelphia, Pa.). 2016 Nov ; 9 (11). 855-865
Foster DJ , Wilson JM , Remke DH , Mahmood MS , Uddin MJ , Wess J , Patel S , Marnett LJ , Niswender CM , Jones CK , Xiang Z , Lindsley CW , Rook JM , Conn PJ , Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Depende… Neuron. 2016 Sep 21; 91 (6). 1244-52
Uddin MI , Evans SM , Craft JR , Capozzi ME , McCollum GW , Yang R , Marnett LJ , Uddin MJ , Jayagopal A , Penn JS , In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Scientific reports. 2016 Aug 5; 6 31011

2015

Uddin MI , Evans SM , Craft JR , Marnett LJ , Uddin MJ , Jayagopal A , Applications of azo-based probes for imaging retinal hypoxia. ACS medicinal chemistry letters. 2015 Apr 9; 6 (4). 445-9
Wauchope O , Beavers WN , Galligan JJ , Mitchener M , Kingsley PJ , Marnett LJ , Nuclear oxidation of a major peroxidation DNA adduct, M1dG, in the Genome. Chemical Research in Toxicology. 2015 Oct 15;
Wang JW , Woodward DF , Martos JL , Cornell CL , Carling RW , Kingsley PJ , Marnett LJ , Multitargeting of selected prostanoid receptors provides agents with enhanced anti-inflammatory acti… FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Sep 29;
Mitchener MM , Hermanson DJ , Shockley EM , Brown HA , Lindsley CW , Reese J , Rouzer CA , Lopez CF , Marnett LJ , Competition and allostery govern substrate selectivity of cyclooxygenase-2. Proceedings of the National Academy of Sciences of the United States of America. 2015 Oct 6; 112 (40). 12366-71
DeGuire SM , Earl DC , Du Y , Crews BA , Jacobs AT , Ustione A , Daniel C , Chong KM , Marnett LJ , Piston DW , Bachmann BO , Sulikowski GA , Fluorescent Probes of the Apoptolidins and their Utility in Cellular Localization Studies. Angewandte Chemie (International ed. in English). 2015 Jan 12; 54 (3). 961-4
Chang SC , Fedeles BI , Wu J , Delaney JC , Li D , Zhao L , Christov PP , Yau E , Singh V , Jost M , Drennan CL , Marnett LJ , Rizzo CJ , Levine SS , Guengerich FP , Essigmann JM , Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in v… Nucleic acids research. 2015 Apr 2;
Blobaum AL , Xu S , Rowlinson SW , Duggan KC , Banerjee S , Kudalkar SN , Birmingham WR , Ghebreselasie K , Marnett LJ , Action at a Distance: Mutations of Peripheral Residues Transform Rapid Reversible Inhibitors to Slow… The Journal of biological chemistry. 2015 Mar 30;
Ra H , González-González E , Uddin MJ , King BL , Lee A , Ali-Khan I , Marnett LJ , Tang JY , Contag CH , Detection of Non-Melanoma Skin Cancer by in vivo Fluorescence Imaging with Fluorocoxib A. Neoplasia (New York, N.Y.). 2015 Feb ; 17 (2). 201-7
Aluise CD , Camarillo JM , Shimozu Y , Galligan JJ , Rose KL , Tallman KA , Marnett LJ , Site-Specific, Intramolecular Cross-Linking of Pin1 Active Site Residues by the Lipid Electrophile 4… Chemical research in toxicology. 2015 Mar 18;
Kudalkar SN , Nikas SP , Kingsley PJ , Xu S , Galligan JJ , Rouzer CA , Banerjee S , Ji L , Eno MR , Makriyannis A , Marnett LJ , 13-methylarachidonic Acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclo… The Journal of biological chemistry. 2015 Mar 20; 290 (12). 7897-909
Neumann W , Xu S , Sárosi MB , Scholz MS , Crews BC , Ghebreselasie K , Banerjee S , Marnett LJ , Hey-Hawkins HC , nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2. ChemMedChem. 2015 Jun 18;
Wilson AJ , Fadare O , Beeghly-Fadiel A , Son DS , Liu Q , Zhao S , Saskowski J , Uddin MJ , Daniel C , Crews B , Lehmann BD , Pietenpol JA , Crispens MA , Marnett LJ , Khabele D , Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous … Oncotarget. 2015 May 4;
Uddin MJ , Crews BC , Ghebreselasie K , Daniel CK , Kingsley PJ , Xu S , Marnett LJ , Targeted imaging of cancer by fluorocoxib C, a near-infrared cyclooxygenase-2 probe. Journal of biomedical optics. 2015 May ; 20 (5). 50502

2014

Derewacz DK , McNees CR , Scalmani G , Covington CL , Shanmugam G , Marnett LJ , Polavarapu PL , Bachmann BO , Structure and Stereochemical Determination of Hypogeamicins from a Cave-Derived Actinomycete. Journal of natural products. 2014 Jul 21;
Beavers WN , Serwa R , Shimozu Y , Tallman KA , Vaught M , Dalvie ED , Marnett LJ , Porter NA , ω-Alkynyl Lipid Surrogates for Polyunsaturated Fatty Acids: Free Radical and Enzymatic Oxidations. Journal of the American Chemical Society. 2014 Jul 17;
Bluett RJ , Gamble-George JC , Hermanson DJ , Hartley ND , Marnett LJ , Patel S , Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocanna… Translational psychiatry. 2014 ; 4 e408
Neumann W , Crews BC , Sárosi MB , Daniel CM , Ghebreselasie K , Scholz MS , Marnett LJ , Hey-Hawkins E , Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance. ChemMedChem. 2014 Oct 15;
Manna JD , Wepy JA , Hsu K , Chang JW , Cravatt BF , Marnett LJ , Identification of the Major Prostaglandin Glycerol Ester Hydrolase in Human Cancer Cells. The Journal of biological chemistry. 2014 Oct 9;
Shuck SC , Wauchope OR , Rose KL , Kingsley PJ , Rouzer CA , Shell SM , Sugitani N , Chazin WJ , Zagol-Ikapitte I , Boutaud O , Oates JA , Galligan JJ , Beavers WN , Marnett LJ , Protein modification by adenine propenal. Chemical research in toxicology. 2014 Oct 20; 27 (10). 1732-42
Singh V , Fedeles BI , Li D , Delaney JC , Kozekov ID , Kozekova A , Marnett LJ , Rizzo CJ , Essigmann JM , Mechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ket… Chemical research in toxicology. 2014 Sep 15; 27 (9). 1619-31
Galligan JJ , Rose KL , Beavers WN , Hill S , Tallman KA , Tansey WP , Marnett LJ , Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigeneti… Journal of the American Chemical Society. 2014 Aug 27; 136 (34). 11864-6
Xu S , Rouzer CA , Marnett LJ , Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond. IUBMB life. 2014 Dec 23;
Shonesy BC , Bluett RJ , Ramikie TS , Báldi R , Hermanson DJ , Kingsley PJ , Marnett LJ , Winder DG , Colbran RJ , Patel S , Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signal… Cell reports. 2014 Dec 11; 9 (5). 1644-53
Uddin MJ , Elleman AV , Ghebreselasie K , Daniel CK , Crews BC , Nance KD , Huda T , Marnett LJ , Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors. ACS medicinal chemistry letters. 2014 Nov 13; 5 (11). 1254-8
Xu S , Hermanson DJ , Banerjee S , Ghebreselasie K , Clayton GM , Garavito RM , Marnett LJ , Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Ne… The Journal of biological chemistry. 2014 Jan 14;
Codreanu SG , Ullery JC , Zhu J , Tallman KA , Beavers WN , Porter NA , Marnett LJ , Zhang B , Liebler DC , Alkylation damage by lipid electrophiles targets functional protein systems. Molecular & cellular proteomics : MCP. 2014 Jan 15;
Uddin MJ , Crews BC , Huda I , Ghebreselasie K , Daniel CK , Marnett LJ , Trifluoromethyl fluorocoxib a detects cyclooxygenase-2 expression in inflammatory tissues and human … ACS medicinal chemistry letters. 2014 Apr 10; 5 (4). 446-50
Rietjens IM , Cohen SM , Fukushima S , Gooderham NJ , Hecht SS , Marnett LJ , Smith B , Adams T , Bastaki M , Harman C , Taylor S , The impact of structural and metabolic variation on the toxicity and carcinogenicity of hydroxy- and… Chemical research in toxicology. 2014 May 23;
Hermanson DJ , Gamble-George JC , Marnett LJ , Patel S , Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentatio… Trends in pharmacological sciences. 2014 May 17;
Perrone MG , Malerba P , Uddin MJ , Vitale P , Panella A , Crews BC , Daniel CK , Ghebreselasie K , Nickels M , Tantawy MN , Manning HC , Marnett LJ , Scilimati A , PET radiotracer [(18)F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preli… European journal of medicinal chemistry. 2014 Jun 10; 80 562-8
Neumann W , Crews BC , Marnett LJ , Hey-Hawkins E , Conjugates of Cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming Cisplati… ChemMedChem. 2014 Jun ; 9 (6). 1150-3
Marnett LJ , Cohen SM , Fukushima S , Gooderham NJ , Hecht SS , Rietjens IM , Smith RL , Adams TB , Bastaki M , Harman CL , McGowen MM , Taylor SV , GRASr2 evaluation of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally re… Journal of food science. 2014 Apr ; 79 (4). R428-41

2013

Maddukuri L , Shuck SC , Eoff RL , Zhao L , Rizzo CJ , Guengerich FP , Marnett LJ , Replication, Repair, and Translesion Polymerase Bypass of N(6)-Oxopropenyl-2 Prime-deoxyadenosine. Biochemistry. 2013 Dec 3; 52 (48). 8766-76
Shuck SC , Rose KL , Marnett LJ , Mass Spectrometric Methods for the Analysis of Nucleoside-Protein Cross-Links: Application to Oxopro… Chemical research in toxicology. 2013 Dec 20;
Windsor MA , Valk PL , Xu S , Banerjee S , Marnett LJ , Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumira… Bioorganic & medicinal chemistry letters. 2013 Nov 1; 23 (21). 5860-4
Liu Q , Ullery J , Zhu J , Liebler DC , Marnett LJ , Zhang B , RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome resp… Molecular bioSystems. 2013 Sep 20;
Hermanson DJ , Hartley ND , Gamble-George J , Brown N , Shonesy BC , Kingsley PJ , Colbran RJ , Reese J , Marnett LJ , Patel S , Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. Nature neuroscience. 2013 Sep ; 16 (9). 1291-8
Aldrovandi M , Hammond VJ , Podmore H , Hornshaw M , Clark SR , Marnett LJ , Slatter DA , Murphy RC , Collins PW , O'Donnell VB , Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibi… Journal of lipid research. 2013 Nov ; 54 (11). 3085-97
Soares CO , Boiani M , Marnett LJ , Bechara EJ , Cytotoxicity of 1,4-diamino-2-butanone, a putrescine analogue, to RKO cells: mechanism and redox imb… Free radical research. 2013 Sep ; 47 (9). 672-82
Blobaum AL , Uddin MJ , Felts AS , Crews BC , Rouzer CA , Marnett LJ , The 2 Prime-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor. ACS medicinal chemistry letters. 2013 May 9; 4 (5). 486-490
Mohebati A , Milne GL , Zhou XK , Duffield-Lillico AJ , Boyle JO , Knutson A , Bosworth BP , Kingsley PJ , Marnett LJ , Brown PH , Akpa EG , Szabo E , Dannenberg AJ , Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers. Cancer prevention research (Philadelphia, Pa.). 2013 Jul ; 6 (7). 646-55
Cekanova M , Uddin MJ , Bartges JW , Callens A , Legendre AM , Rathore K , Wright L , Carter A , Marnett LJ , Molecular imaging of cyclooxygenase-2 in canine transitional cell carcinomas in vitro and in vivo. Cancer prevention research (Philadelphia, Pa.). 2013 May ; 6 (5). 466-76
Uddin MJ , Crews BC , Ghebreselasie K , Marnett LJ , Design, synthesis, and structure-activity relationship studies of fluorescent inhibitors of cycloxyg… Bioconjugate chemistry. 2013 Apr 17; 24 (4). 712-23
Connor RE , Codreanu SG , Marnett LJ , Liebler DC , Targeted protein capture for analysis of electrophile-protein adducts. Methods in molecular biology (Clifton, N.J.). 2013 ; 987 163-76
Liedtke AJ , Adeniji AO , Chen M , Byrns MC , Jin Y , Christianson DW , Marnett LJ , Penning TM , Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β… Journal of medicinal chemistry. 2013 Mar 28; 56 (6). 2429-46
Boiani M , Daniel C , Liu X , Hogarty MD , Marnett LJ , The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistanc… The Journal of biological chemistry. 2013 Mar 8; 288 (10). 6980-90
Tallman KA , Armstrong MD , Milne SB , Marnett LJ , Brown HA , Porter NA , Cobalt carbonyl complexes as probes for alkyne-tagged lipids. Journal of lipid research. 2013 Mar ; 54 (3). 859-68
Sevick-Muraca EM , Akers WJ , Joshi BP , Luker GD , Cutler CS , Marnett LJ , Contag CH , Wang TD , Azhdarinia A , Advancing the translation of optical imaging agents for clinical imaging. Biomedical optics express. 2013 Jan 1; 4 (1). 160-70
Laube M , Neumann W , Scholz M , Lönnecke P , Crews B , Marnett LJ , Pietzsch J , Kniess T , Hey-Hawkins E , 2-Carbaborane-3-phenyl-1H-indoles–synthesis via McMurry reaction and cyclooxygenase (COX) inhibitio… ChemMedChem. 2013 Feb ; 8 (2). 329-35
Aluise CD , Rose K , Boiani M , Reyzer ML , Manna JD , Tallman K , Porter NA , Marnett LJ , Peptidyl-prolyl cis/trans-isomerase A1 (Pin1) is a target for modification by lipid electrophiles. Chemical research in toxicology. 2013 Feb 18; 26 (2). 270-9
Yang Y , Yang H , Wang Z , Varadaraj K , Kumari SS , Mergler S , Okada Y , Saika S , Kingsley PJ , Marnett LJ , Reinach PS , Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory resp… Cellular signalling. 2013 Feb ; 25 (2). 501-11

2012

Musee J , Marnett LJ , Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to pero… The Journal of biological chemistry. 2012 Oct 26; 287 (44). 37383-94
Xu S , Mueser TC , Marnett LJ , Funk MO , Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-bindi… Structure (London, England : 1993). 2012 Sep 5; 20 (9). 1490-7
Scholz M , Blobaum AL , Marnett LJ , Hey-Hawkins E , Ortho-carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors. Bioorganic & medicinal chemistry. 2012 Aug 1; 20 (15). 4830-7
Eisenbrand G , Gates KS , Hecht SS , Janzowski C , Keefer LK , Marnett LJ , Tannenbaum SR , Richard Loeppky (1937-2012). Chemical research in toxicology. 2012 Jun 18; 25 (6). 1155-6
Aldrich MB , Marshall MV , Sevick-Muraca EM , Lanza G , Kotyk J , Culver J , Wang LV , Uddin J , Crews BC , Marnett LJ , Liao JC , Contag C , Crawford JM , Wang K , Reisdorph B , Appelman H , Turgeon DK , Meyer C , Wang T , Seeing it through: translational validation of new medical imaging modalities. Biomedical optics express. 2012 Apr 1; 3 (4). 764-76
Ullery JC , Marnett LJ , Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Inve… Biochimica et biophysica acta. 2012 Oct ; 1818 (10). 2424-35
Marnett LJ , Inflammation and cancer: chemical approaches to mechanisms, imaging, and treatment. The Journal of organic chemistry. 2012 Jun 15; 77 (12). 5224-38
Liedtke AJ , Crews BC , Daniel CM , Blobaum AL , Kingsley PJ , Ghebreselasie K , Marnett LJ , Cyclooxygenase-1-selective inhibitors based on the (E)-2 Prime-des-methyl-sulindac sulfide scaffold. Journal of medicinal chemistry. 2012 Mar 8; 55 (5). 2287-300
Marnett LJ , On a high note. Chemical research in toxicology. 2012 Jan 13; 25 (1). 1
Akingbade D , Kingsley PJ , Shuck SC , Cooper T , Carnahan R , Szekely J , Marnett LJ , Selection of monoclonal antibodies against 6-oxo-M(1)dG and their use in an LC-MS/MS assay for the p… Chemical research in toxicology. 2012 Feb 20; 25 (2). 454-61
Liedtke AJ , Kim K , Stec DF , Sulikowski GA , Marnett LJ , Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkano… Tetrahedron. 2012 Dec 2; 68 (48). 10049-10058
Cekanova M , Uddin MJ , Legendre AM , Galyon G , Bartges JW , Callens A , Martin-Jimenez T , Marnett LJ , Single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygen… Journal of biomedical optics. 2012 Nov ; 17 (11). 116002
Windsor MA , Hermanson DJ , Kingsley PJ , Xu S , Crews BC , Ho W , Keenan CM , Banerjee S , Sharkey KA , Marnett LJ , Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Pro… ACS medicinal chemistry letters. 2012 Sep 13; 3 (9). 759-763