{"id":3507,"date":"2025-04-09T13:17:44","date_gmt":"2025-04-09T18:17:44","guid":{"rendered":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/?p=3507"},"modified":"2025-04-09T13:17:44","modified_gmt":"2025-04-09T18:17:44","slug":"getting-bang-for-your-buck","status":"publish","type":"post","link":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/2025\/04\/09\/getting-bang-for-your-buck\/","title":{"rendered":"Getting bang for your buck"},"content":{"rendered":"<h3><em>Precancer Detection<\/em><\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21536 size-medium aligncenter\" src=\"https:\/\/cdn.vanderbilt.edu\/t2-main\/medschool-prd\/wp-content\/uploads\/sites\/101\/2025\/04\/WCNDD_2-300x214.png\" alt=\"Photo of lab technician at work. Photo: Harrison McClary\/Vanderbilt University\" width=\"300\" height=\"214\" \/>Vanderbilt cell and developmental biologists have made progress in understanding the origins of cancer by studying the precise timing of cellular growth. Their work suggests that colorectal cancer often arises from multiple normal cells in the intestinal lining, not just a single cell. The researchers developed a highly precise molecular \u201cclock\u201d that can track the timing of cellular events at a single-cell level. Their research provides valuable insights into the complex origins of colorectal cancer.<\/p>\n<p><a href=\"https:\/\/medschool.vanderbilt.edu\/basic-sciences\/2024\/10\/31\/determining-the-precise-timing-of-cellular-growth-to-understand-the-origins-of-cancer\/\">Read the full story: Determining the precise timing of cellular growth to understand the origins of cancer.<\/a><\/p>\n<h2><strong>Alzheimer\u2019s disease and schizophrenia<\/strong><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-21529 aligncenter\" src=\"https:\/\/cdn.vanderbilt.edu\/t2-main\/medschool-prd\/wp-content\/uploads\/sites\/101\/2025\/04\/Alzheimers-300x200.png\" alt=\"\" width=\"300\" height=\"200\" \/>The successful clinical trial of VU319, a drug for memory loss in people with Alzheimer\u2019s disease and schizophrenia, marks a significant step forward in the development of Alzheimer\u2019s treatments.<\/p>\n<p>Researchers at the Warren Center for Neuroscience Drug Discovery have completed a phase I single ascending dose clinical trial that demonstrated target engagement and no adverse effects. This milestone highlights Vanderbilt\u2019s ability to drive discovery from research to clinical impact.<\/p>\n<p><a href=\"https:\/\/medschool.vanderbilt.edu\/basic-sciences\/2024\/01\/19\/first-successful-clinical-trial-of-vu319-brings-alzheimers-treatment-one-step-closer\/\">Read the full story: First successful clinical trial of VU319 brings Alzheimer\u2019s treatment one step closer<\/a>.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21525 size-medium aligncenter\" src=\"https:\/\/cdn.vanderbilt.edu\/t2-main\/medschool-prd\/wp-content\/uploads\/sites\/101\/2025\/04\/WCNDD_1-300x182.png\" alt=\"Photo of lab technician in front of lab hood. Photo: Harrison McClary\/Vanderbilt University\" width=\"300\" height=\"182\" \/>WCNDD researchers have also created a new compound that could potentially treat both the positive and negative symptoms of schizophrenia. They propose a novel target and mechanism that could improve cognition\u2014a negative symptom\u2014while also treating the positive symptoms, such as hallucinations.<\/p>\n<p>Further research building on these findings could lead to the development of new compounds that are effective without adverse effects, providing a new therapeutic approach for addressing the comprehensive symptoms of schizophrenia.<\/p>\n<p><a href=\"https:\/\/medschool.vanderbilt.edu\/basic-sciences\/2025\/01\/16\/warren-center-for-neuroscience-drug-discovery-researchers-create-new-compound-to-potentially-treat-negative-and-positive-symptoms-of-schizophrenia\/\">Read the full story: Warren Center for Neuroscience Drug Discovery researchers create new compound to potentially treat negative and positive symptoms of schizophrenia<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>Read <a href=\"https:\/\/medschool.vanderbilt.edu\/basic-sciences\/2025\/04\/02\/getting-bang-for-your-buck\/\">full article here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Precancer Detection Vanderbilt cell and developmental biologists have made progress in understanding the origins of cancer by studying the precise timing of cellular growth. Their work suggests that colorectal cancer often arises from multiple normal cells in the intestinal lining, not just a single cell. The researchers developed a highly precise molecular \u201cclock\u201d that can&#8230;<\/p>\n","protected":false},"author":564,"featured_media":3508,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[30],"class_list":["post-3507","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-group-news","tag-news"],"acf":[],"jetpack_featured_media_url":"https:\/\/cdn.vanderbilt.edu\/t2-main\/lab-prd\/wp-content\/uploads\/sites\/116\/2025\/04\/WCNDD_1-1024x620-1.png","jetpack_shortlink":"https:\/\/wp.me\/pg6bwg-Uz","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/posts\/3507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/users\/564"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/comments?post=3507"}],"version-history":[{"count":1,"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/posts\/3507\/revisions"}],"predecessor-version":[{"id":3509,"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/posts\/3507\/revisions\/3509"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/media\/3508"}],"wp:attachment":[{"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/media?parent=3507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/categories?post=3507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/lindsleylab\/wp-json\/wp\/v2\/tags?post=3507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}