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Lindsley Lab

Jerri Rook, Ph.D.

Assistant Professor of Pharmacology |
Director of Behavioral Pharmacology

B.A. Drury University, 2000
Biology/Chemistry
Ph.D. University of Kansas Medical Center, 2008
Pharmacology

Phone: (615) 322-6730 Fax: (615) 343-3088 Email: jerri.m.rook@vanderbilt.edu Location: 8405 MRB IV (Langford)


Mailing Address:
 Vanderbilt University/VCNDD
1205 Light Hall
Nashville, TN 37232-0697

Biosketch and Research Interests

Dr. Rook is a Research Instructor in the Department of Pharmacology at Vanderbilt University in the Vanderbilt Center for Neuroscience Drug Discovery. She received her Ph.D. degree in Pharmacology from the University of Kansas Medical Center in 2008 where she was supported by the KUMC Biomedical Research Training Program Award. She then pursued her postdoctoral studies in the laboratory of P. Jeffrey Conn, Ph.D. at Vanderbilt University where she was a postdoctoral member of the Vanderbilt Brain Institute. Dr. Rook has served as an author on several primary research articles in peer-reviewed scientific journals and frequently presents her work at both national and international meetings. She is currently the member of the American Society for Pharmacology and Experimental Therapeutics, Society for Neuroscience, and International Society for Neurochemistry. Dr. Rook has received multiple awards including the Ruth L. Kirschstein National Research Service Award from the National Institute of Mental Health in 2009, the Alzheimer’s Drug Discovery Foundation and Charles River Laboratories International, Inc. 2011 partnership award, and is the recent recipient of the Edward N. & Della L. Thome Memorial Foundation award program in Alzheimer’s disease drug discovery research.

Dr. Rook is a highly trained behavioral and systems neuropharmacologist who has a great deal of expertise with the use of biochemistry, molecular biology, behavioral pharmacology and imaging techniques to study the in vivo e
Roy, R.N.; Carlsten, J.A.; Niederschmidt, J.; Good, W.S.; Rook, J.M.; Brewe, C.; Kilker, A.J.; Roy, L.N.; Kuhler, K.M. ‘Buffers for the physiological pH range: Thermodynamic constants of substituted aminopropanesulfonic acids from 5 to 55°C’ Journal of Solution Chemistry (1997); 26(3): 309-317. {DOI: 10.1007/BF02768001}

Roy, R.N.; Moore, C.P.; Carlsten, J.A.; Good, W.S.; Harris, P.; Rook, J.M.; Roy, L.N.; Kuhler, K.M. ‘Second Dissociation Constant of Two Substituted Aminomethanesulfonic Acids in Water from 5 to 55°C’ Journal of Solution Chemistry (1997); 26(12): 1209-1216. {DOI: 10.1023/A:1022937324983}ffects of GPCR ligands in preclinical animal models. She has made a number of contributions to the understanding of the roles of mGlu5 in the regulation of brain function and behavior and in the development of novel therapeutic strategies for the treatment of central nervous system disorders. Currently, Dr. Rook is focused on the discovery of novel therapeutic strategies for the treatment of cognitive deficits associated with schizophrenia and Alzheimer’s disease.

Selected Publications

Rook, J.M.; Noetzel, M.J.; Pouliot, W.A.; Bridges, T.M.; Vinson, P.N.; Cho, H.P.; Zhou, Y.; Gogliotti, R.D.; Manka, J.T.; Gregory, K.J.; Stauffer, S.R.; Dudek, F.E.; Xiang, Z.; Niswender, C.M.; Daniels, J.S.; Jones, C.K.; Lindsley, C.W.; Conn, P.J. ‘Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity’ Biological Psychiatry (2013); 73(6): 501-509. {DOI: 10.1016/j.biopsych.2012.09.012; PMID: 23140665}

Gregory, K.J.; Noetzel, M.J.; Rook, J.M.; Vinson, P.N.; Stauffer, S.R.; Rodriguez, A.L.; Emmitte, K.A.; Zhou, Y.; Chun, A.C.; Felts, A.S.; Chauder, B.A.; Lindsley, C.W.; Niswender, C.M.; Conn, P.J. ‘Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships’ Molecular Pharmacology (2012); 82(5): 860-875. {DOI: 10.1124/mol.112.080531; PMID: 22863693}

Noetzel, M.J.*; Rook, J.M.*; Vinson, P.N.; Cho, H.P.; Days, E.; Zhou, Y.; Rodriguez, A.L.; Lavreysen, H.; Stauffer, S.R.; Niswender, C.M.; Xiang, Z.; Daniels, J.S.; Jones, C.K.; Lindsley, C.W.; Weaver; C.D.; Conn, P.J. ‘Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function’ Molecular Pharmacology (2012); 81(2): 120-133. *Both contributed equally. {DOI: 10.1124/mol.111.075184; PMID: 22021324}

Sheffler, D.J.; Gregory, K.J.; Rook, J.M.; Conn, P.J. ‘ Allosteric modulation of metabotropic glutamate receptors’ Advances in Pharmacology (2011); 62: 37-77. {DOI: 10.1016/B978-0-12-385952-5.00010-5; PMID: 21907906}

Tantawy, M.N.; Peterson, T.E.; Jones, C.K.; Johnson, K.; Rook, J.M.; Conn, P.J.; Baldwin, R.M.; Ansari, M.S.; Kessler, R.M. ‘Impact of isoflurane anesthesia on D2 receptor occupancy by [18F]fallypride measured by microPET with a modified Logan plot’ Synapse (2011); 65(11): 1173-1180. {DOI: 10.1002/syn.20955; PMID: 21584868}

Rodriguez, A.L.; Grier, M.D.; Jones, C.K.; Herman, E.J.; Kane, A.S.; Smith, R.L.; Williams, R.; Zhou, Y.; Marlo, J.E.; Days, E.L.; Blatt, T.N.; Jadhav, S.; Menon, U.N.; Vinson, P.N.; Rook, J.M.; Stauffer, S.R.; Niswender, C.M.; Lindsley, C.W.; Weaver; C.D.; Conn, P.J. ‘Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity’ Molecular Pharmacology (2010); 78: 1105-1123. {DOI: 10.1124/mol.110.067207; PMID: 20923853}

Sharma, S.; Kedrowski, J.; Rook, J.M.; Barrett, R.S.; Jones, C.K.; Rodriguez, A.L.; Conn, P.J.; Lindsley CW. ‘Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines’ Journal of Medicinal Chemistry (2009); 52(14): 4103-4106. {DOI: 10.1021/jm900654c; PMID: 19537763} Rook, J.M.; Hasan, W.; McCarson, K.E. ‘Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression’ Biochemical Pharmacology (2009); 77(11): 1747-1755. {DOI: 10.1016/j.bcp.2009.03.003; PMID: 19428329} Rook, J.M.; Hasan, W.; McCarson, K.E. ‘Temporal effects of topical morphine application on cutaneous wound healing’ Anesthesiology (2008); 109(1): 130-136. {DOI: 10.1097/ALN.0b013e31817b5ac3; PMID: 18580183} Rook, J.M.; McCarson, K.E. ‘Delay of cutaneous wound closure by morphine via local blockade of peripheral tachykinin release’ Biochemical Pharmacology (2007); 74(5): 752-757. {DOI: 10.1016/j.bcp.2007.06.005; PMID: 17632084}