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Aaron Bender, Ph.D.

Drug Discovery Scientist I

B.A. Albion College, 2011
Ph.D. University Of Michigan, 2016
Medicinal Chemistry

Phone: (615) 322-7415
Fax: (615) 778-1414
Location: Cool Springs Innovation Park

Mailing Address:

Vanderbilt University/WCNDD
Cool Springs Innovation Park
393 Nichol Mill Lane, Room 1001
Franklin, TN 37067

Biosketch and Research Interests

Aaron earned his PhD in medicinal chemistry (organic synthesis focus) from the University of Michigan in 2016, working on the synthesis of mixed efficacy opioid ligands under the direction of Dr. Henry Mosberg.

Aaron joined the Lindsley lab as a Post Doc in 2016, and is currently working on the synthesis of positive allosteric modulators (PAMs) for the muscarinic acetylcholine receptor M5.

Aaron’s research interests are in medicinal chemistry, particularly the development of therapeutics for CNS disorders, and organic synthesis.

Selected Publications

Turkett, J.A.; Ringuette, A.E.; Lindsley, C.W.; Bender, A.M. ‘Synthesis of Substituted 6,7-Dihydro-5H-pyrrolo[2,3-c]pyridazines/pyrazines via Catalyst-Free Tandem Hydroamination–Aromatic Substitution’ Journal of Organic Chemistry (2020); XX(XX): XXX-XXX. {DOI: 10.1021/acs.joc.9b03463; PMID: 32227869}

Bender, A.M.; Cho, H.P.; Nance, K.D.; Lingenfelter, K.S.; Luscombe, V.B.; Gentry, P.R.; Voigtritter, K.; Berizzi, A.E.; Sexton, P.M.; Langmead, C.J.; Christopoulos, A.; Locuson, C.W.; Bridges, T.M.; Chang, S.; O’Neill, J.C.; Zhan, X.; Niswender, C.M.; Jones, C.J.; Conn, P.J.; Lindsley, C.W. ‘Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold’ ACS Chemical Neuroscience (2018); 9(7): 1572-1581. {DOI: 10.1021/acschemneuro.8b00126; PMID: 29678111}

Bender, A.M.; Chopko, T.C..; Bridges, T.M.; Lindsley, C.W. ‘Preparation of Unsymmetrical 1,2,4,5-Tetrazines via a Mild Suzuki Cross-Coupling Reaction’ Organic Letters (2017); 19(20): 5693-5696. {DOI: 10.1021/acs.orglett.7b02868; PMID: 28976768}

Bender, A.M.; Griggs, N.W.; Anand, J.P.; Traynor, J.R.; Jutkiewicz, E.M.; Mosberg, H.I. ‘Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands’ ACS Chemical Neuroscience (2015); 6(8): 1428-1435. {DOI: 10.1021/acschemneuro.5b00100}