Lindsley Lab

Education

Louisiana State University, 1998
B.S Biochemistry

Louisiana State University, 2000
M.S. Chemistry

University of Texas at Austin, 2005
Ph.D. Organic Chemistry

Biosketch and Research Interests

Julie received her Ph.D. in organic chemistry from the University of Texas at Austin under the direction of Professor Brian L. Pagenkopf. Her research focused on the design and synthesis of bisoxazoline-salen ligands for asymmetric catalytic reactions. She was a recipient of The Gates Millennium Scholarship from the Bill and Melinda Gates Foundation.

In 2005, Julie joined the faculty of the Department of Chemistry at Rhodes College, Memphis, TN as an assistant professor. Her primary research interests included asymmetric catalysis with applications toward the synthesis of therapeutically relevant compounds such as anti-malarial alkaloid febrifugine.

Production Centers Network (MLPCN). In this position, her primary responsibilities involved management of the work-flow among various groups of the synthetic and medicinal chemistry core within the center.

As Research Assistant Professor, Julie is one of the lead chemists in Medicinal Chemistry Team focusing on the pursuit of novel small molecule for the treatment of Alzheimer’s disease, Schizophrenia, Parkinson’s disease, anxiety and other neurological disorders.

Selected Publications

Engers, J.L.; Baker, L.A.; Chang, S.; Luscombe, V.B.; Rodriguez, A.L.; Niswender, C.M.; Cho, H.P.; Bubser, M.; Thompson-Gray, A.; Jones, C.K.; Peng, W.; Rook, J.M.; Bridges, T.M.; Boutaud, O.; Conn, P.J.; Engers, D.W.; Lindsley, C.W.; Temple K.J. ‘Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)’ ACS Chemical Neuroscience (2024); 15 (20): 3744-3754. DOI: 10.1021/acschemneuro.4c00465.

Engers, J.L.; Bollinger, K.A.; Capstick, R.A.; Long, M.F.; Bender, A.M.; Dickerson, J.W.; Peng, M.; Presley, C.C.; Cho, H.P.; Rodriguez, A.L.; Niswender, C.M.; Moran, S.P.; Xiang, Z.; Blobaum, A.L.; Boutaud, O.; Rook, J.M.; Engers, D.W.; Conn, P.J.; Lindsley, C.W. ‘Discovery of VU6007496: Challenges in the Development of an M₁ Positive Allosteric Modulator Backup Candidate’ ACS Chemical Neuroscience (2024); 15 (18): 3421-3433. DOI: 10.1021/acschemneuro.4c00508.

Li, J.; Orsi, D.L.; Engers, J.L.; Long, M.F.; Capstick, R.A.; Maurer, M.A.; Presley, C.C.; Vinson, P.N.; Rodriguez, A.L.; Han, A.; Cho, H.P.; Chang, S.; Jackson, M.; Michael, B.; Blobaum, A.L.; Boutaud, O.; Nader, M.A.; Niswender, C.M.; Conn, P.J.; Jones, C.K.; Lindsley, C.W.; Han, C. ‘Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M₅ Muscarinic Acetylcholine Receptor’ Journal of Medicinal Chemistry (2024); 67(16): 14394-14413.  DOI: 10.1021/acs.jmedchem.4c01193

Additional publications can be found here: https://orcid.org/0009-0004-3654-5464