Publications_old

2022

A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane
Chun-Wei Lin, Laura M. Nocka, Brittany L. Stinger, Joseph B. DeGrandchamp, L.J. Nugent Lew, Steven Alvarez, Henry T. Phan, Yasushi Kondo, John Kuriyan and Jay T. Groves

Proc Natl Acad Sci USA 2022 119(19):e2122531119 https://doi.org/10.1073/pnas.2122531119

BioRχiv 2021.12.12.472247; doi: https://doi.org/10.1101/2021.12.12.472247

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras
Frank Hidalgo, Laura M. Nocka, Neel H. Shah, Kent Gorday, Naomi R. Latorraca, Pradeep Bandaru, Sage Templeton, David Lee, Deepti Karandur, Jeffery G. Pelton, Susan Marqusee, David E. Wemmer and John Kuriyan

eLife 2022;11:e76595
doi: 10.7554/eLife.76595

2021

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor
Yongjian Huang, Jana Ognjenović, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam and John Kuriyan

eLife 2021 10:e73218  doi:10.7554/eLife.73218

BioRχiv 2020.12.08.417006; doi: https://doi.org/10.1101/2020.12.08.417006

 

Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases
Helen T Hobbs, Neel H Shah, Jean M Badroos, Christine L Gee, Susan Marqusee and John Kuriyan

Protein Science 2021 30:2373–2384  Epub October 3  doi:10.1002/pro.4199

BioRχiv 2021.07.20.453126;
doi:https://doi.org/10.1101/2021.07.20.453126

 

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction
Subu Subramanian, Kent Gorday, Kendra Marcus, Matthew R. Orellana, Peter Ren, Xiao Ran Luo, Mike O’Donnell and John Kuriyan

eLife 2021;10:e66181  doi:10.7554/eLife.66181

BioRχiv 2020.12.31.424921;
doi:https://doi.org/10.1101/2020.12.31.424921