Publications

2025

NJ Guzikowski, CD Gailey, DM Miller III, ET Kavalali (2025) RIM Mutants Occlude the Effects of Aliphatic Alcohols on C. elegans Locomotion MicroPubl Biol. 2025 Jun 12;2025:10.17912/micropub.biology.001611. doi: 10.17912/micropub.biology.001611. eCollection 2025.

ZZ Ma, NJ Guzikowski, JW Kim, ET Kavalali, LM Monteggia (2025) Enhanced ERK activity extends ketamine’s antidepressant effects by augmenting synaptic plasticity Science. 2025 May 8;388(6747):646-655. doi: 10.1126/science.abb6748. Epub 2025 May 8.PMID: 40339008

MK Piazza, AR Weit, ET Kavalali, JL Neul, LM Monteggia (2025) MeCP2 prevents against sustained ketamine-induced synaptic depression at inhibitory synapses iScience. 2025 Apr 21;28(6):112485. doi: 10.1016/j.isci.2025.112485. eCollection 2025 Jun 20.PMID: 40612906

2024

Guzikowski NJ, Kavalali ET (2024) Functional specificity of liquid-liquid phase separation at the synapse. Nature Communications 2024 Nov 21;15(1):10103. doi: 10.1038/s41467-024-54423-7.PMID: 39572583

Kavalali ET, Monteggia LM (2024) Synaptic basis of rapid antidepressant action European Archives Psychiatry Clinical Neuroscience 2024 Sep 29. doi: 10.1007/s00406-024-01898-6. PMID: 39343821

Afuwape OAT, Chanaday NL, Kasap M, Monteggia LM, Kavalali ET (2024) Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins J Physiol. 2024 Aug 14:10.1113/JP286711. doi: 10.1113/JP286711. Online ahead of print.PMID: 39141823

Bagatelas ED, Kavalali ET (2024) Chronic modulation of cAMP signaling elicits synaptic scaling irrespective of activity. iScience 2024 Jun 5;27(7):110176. doi: 10.1016/j.isci.2024.110176. eCollection 2024 Jul 19. PMID: 38989459

Kim JW, Kleinfelter B, Kavalali ET, Monteggia LM (2024) Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine. Neuropsychopharmacology. 2024 Nov;49(12):1916-1924. doi: 10.1038/s41386-024-01908-0. Epub 2024 Jul 1. PMID: 38956176

Piazza MK, Kavalali ET, Monteggia LM (2024) Ketamine induced synaptic plasticity operates independently of long-term potentiation. Neuropsychopharmacology. 2024 Oct;49(11):1758-1766. doi: 10.1038/s41386-024-01895-2. Epub 2024 Jun 19. PMID: 38898206

Houcek A, Ma ZZ, Trauterman B, Uzay B, Monteggia LM, Kavalali ET (2024) CRISPR-Cas9 editing of synaptic genes in human embryonic stem cells for functional analysis in induced human neurons. STAR Protoc. 2024 Jun 21;5(2):103089. doi: 10.1016/j.xpro.2024.103089. Epub 2024 May 24. PMID: 38795356

McCarthy CI, Kavalali ET (2024) Nano-organization of synaptic calcium signaling. Biochem Soc Trans. 2024 Jun 26;52(3):1459-1471. doi: 10.1042/BST20231385. PMID: 38752834

Wang CS, McCarthy CI, Guzikowski NJ, Kavalali ET, Monteggia LM (2024) Brain-derived neurotrophic factor scales presynaptic calcium transients to modulate excitatory neurotransmission. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2303664121. doi: 10.1073/pnas.2303664121. Epub 2024 Apr 15. PMID: 38621124

Guzikowski NJ, Kavalali ET (2024) Synaptic vesicle pool heterogeneity drives an anomalous form of synaptic plasticity. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2401734121. doi: 10.1073/pnas.2401734121. Epub 2024 Feb 29. PMID: 38422062

Kim JW, Suzuki K, Kavalali ET, Monteggia LM (2024) Ketamine: Mechanisms and Relevance to Treatment of Depression. Annu Rev Med. 2024 Jan 29;75:129-143. doi: 10.1146/annurev-med-051322-120608. Epub 2023 Sep 20. PMID: 37729028

Krystal JH, Kavalali ET, Monteggia LM (2024) Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms Neuropsychopharmacology. 2024 Jan;49(1):41-50. doi: 10.1038/s41386-023-01629-w. Epub 2023 Jul 24. PMID: 37488280

2023

Kim JW, Suzuki K, Kavalali ET, Monteggia LM. (2023) Ketamine: Mechanisms and Relevance to Treatment of Depression. Annu Rev Med. 2024 Jan 29;75:129-143. doi: 10.1146/annurev-med-051322-120608. Epub 2023 Sep 20. PMID: 37729028

Krystal JH, Kavalali ET, Monteggia LM (2023) Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms. Neuropsychopharmacology. 2024 Jan;49(1):41-50. doi: 10.1038/s41386-023-01629-w. Epub 2023 Jul 24. PMID: 37488280

Uzay, B., & Kavalali, E. T. (2023). Genetic disorders of neurotransmitter release machinery. Frontiers in synaptic neuroscience, 15, 1148957. https://doi.org/10.3389/fnsyn.2023.1148957

Kavalali E. T. (2023). Interrogating synaptic transmission at circadian time scales. The Journal of physiology, 601(10), 1697–1698. https://doi.org/10.1113/JP284668

Kim, J. W., Suzuki, K., Kavalali, E. T., & Monteggia, L. M. (2023). Bridging rapid and sustained antidepressant effects of ketamine. Trends in molecular medicine, 29(5), 364–375. https://doi.org/10.1016/j.molmed.2023.02.003

Guzikowski NJ, Kavalali ET. Super-resolution imaging of synaptic scaffold proteins in rat hippocampal neurons. STAR Protoc. 2023 Feb 2;4(1):102080. doi: 10.1016/j.xpro.2023.102080. Epub ahead of print. PMID: 36853692; PMCID: PMC9932186.

Uzay B, Houcek A, Ma ZZ, Konradi C, Monteggia LM, Kavalali ET (2023). Neurotransmitter Release Progressively Desynchronizes in Induced Human Neurons during Synapse Maturation and Aging. Cell Reports 42:112042.

Jaczynska, K., Esquivies, L., Pfuetzner, R. A., Alten, B., Brewer, K. D., Zhou, Q., Kavalali, E. T., Brunger, A. T., & Rizo, J. (2023). Analysis of tripartite Synaptotagmin-1-SNARE-complexin-1 complexes in solution. FEBS open bio, 13(1), 26–50. https://doi.org/10.1002/2211-5463.13503

Kavalali, E. T., & Monteggia, L. M. (2023). Rapid homeostatic plasticity and neuropsychiatric therapeutics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 48(1), 54–60. https://doi.org/10.1038/s41386-022-01411-4

2022

Matthews, E. A., Sun, W., McMahon, S. M., Doengi, M., Halka, L., Anders, S., Müller, J. A., Steinlein, P., Vana, N. S., van Dyk, G., Pitsch, J., Becker, A. J., Pfeifer, A., Kavalali, E. T., Lamprecht, A., Henneberger, C., Stein, V., Schoch, S., & Dietrich, D. (2022). Optical analysis of glutamate spread in the neuropil. Cerebral cortex (New York, N.Y. : 1991), 32(17), 3669–3689. https://doi.org/10.1093/cercor/bhab440

Guzikowski NJ, Kavalali ET. Nano-organization of spontaneous GABAergic transmission directs its autonomous function in neuronal signaling. Cell Rep. 2022 Aug 9;40(6):111172. doi: 10.1016/j.celrep.2022.111172. PMID: 35947950; PMCID: PMC9392417.

Horvath, P. M., Piazza, M. K., Kavalali, E. T., & Monteggia, L. M. (2022). MeCP2 loss-of-function dysregulates microRNAs regionally and disrupts excitatory/inhibitory synaptic transmission balance. Hippocampus, 32(8), 610–623. https://doi.org/10.1002/hipo.23455

Uzay, B., & Kavalali, E. T. (2022). Multi-neurotransmitter regulation of neural firing via coincidence of parallel G-protein signals. Cell calcium, 105, 102611. https://doi.org/10.1016/j.ceca.2022.102611

Suzuki K, Kavalali ET, Monteggia LM. Optical analysis of AMPAR-mediated synaptic scaling in mouse hippocampus. STAR Protoc. 2022 Jun 4;3(2):101443. doi: 10.1016/j.xpro.2022.101443. PMID: 35677613; PMCID: PMC9168154.

Wang CS, Chanaday NL, Monteggia LM, Kavalali ET. Probing the segregation of evoked and spontaneous neurotransmission via photobleaching and recovery of a fluorescent glutamate sensor. Elife. 2022 Apr 14;11:e76008. doi: 10.7554/eLife.76008. PMID: 35420542; PMCID: PMC9129874.

Chanaday, N. L., & Kavalali, E. T. (2022). Role of the endoplasmic reticulum in synaptic transmission. Current opinion in neurobiology, 73, 102538. https://doi.org/10.1016/j.conb.2022.102538

Alten B, Guzikowski NJ, Zurawski Z, Hamm HE, Kavalali ET. Presynaptic mechanisms underlying GABA_B-receptor-mediated inhibition of spontaneous neurotransmitter release. Cell Rep. 2022 Jan 18;38(3):110255. doi: 10.1016/j.celrep.2021.110255. PMID: 35045279; PMCID: PMC8793855.

2021

Wang, C. S., Kavalali, E. T., & Monteggia, L. M. (2022). BDNF signaling in context: From synaptic regulation to psychiatric disorders. Cell, 185(1), 62–76. https://doi.org/10.1016/j.cell.2021.12.003

Guzikowski NJ, Kavalali ET. Nano-Organization at the Synapse: Segregation of Distinct Forms of Neurotransmission. Front Synaptic Neurosci. 2021 Dec 22;13:796498. doi: 10.3389/fnsyn.2021.796498. PMID: 35002671; PMCID: PMC8727373.

Suzuki, K., Kim, J. W., Nosyreva, E., Kavalali, E. T., & Monteggia, L. M. (2021). Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action. Cell reports, 37(5), 109918. https://doi.org/10.1016/j.celrep.2021.109918

Chanaday, N. L., & Kavalali, E. T. (2021). Synaptobrevin-2 dependent regulation of single synaptic vesicle endocytosis. Molecular biology of the cell, 32(19), 1818–1823. https://doi.org/10.1091/mbc.E21-04-0213

Lin PY, Ma ZZ, Mahgoub M, Kavalali ET, Monteggia LM. A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant action. Cell Rep. 2021 Aug 17;36(7):109513. doi: 10.1016/j.celrep.2021.109513. PMID: 34407417; PMCID: PMC8404212.

Horvath, P. M., Chanaday, N. L., Alten, B., Kavalali, E. T., & Monteggia, L. M. (2021). A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. Cell reports, 36(5), 109467. https://doi.org/10.1016/j.celrep.2021.109467

Kim, J. W., Autry, A. E., Na, E. S., Adachi, M., Björkholm, C., Kavalali, E. T., & Monteggia, L. M. (2021). Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation. Nature neuroscience, 24(8), 1100–1109. https://doi.org/10.1038/s41593-021-00868-8

Shumate, K. M., Tas, S. T., Kavalali, E. T., & Emeson, R. B. (2021). RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission. Journal of neurochemistry, 158(2), 182–196. https://doi.org/10.1111/jnc.15372

Shin, O. H., & Kavalali, E. T. (2021). Evolutionary diversity of the dual Ca²⁺ sensor system for neurotransmitter release. Cell calcium, 96, 102402. https://doi.org/10.1016/j.ceca.2021.102402

Kim JW, Herz J, Kavalali ET, Monteggia LM. A key requirement for synaptic Reelin signaling in ketamine-mediated behavioral and synaptic action. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2103079118. doi: 10.1073/pnas.2103079118. PMID: 33975959; PMCID: PMC8157952.

Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET (2021). Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress. Neuron 109:1314-1332.e5.

Vilcaes AA, Chanaday NL, Kavalali ET. Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles. Neuron. 2021 Mar 17;109(6):971-983.e5. doi: 10.1016/j.neuron.2021.01.007. Epub 2021 Jan 28. PMID: 33513363; PMCID: PMC7979516.

Alten B, Zhou Q, Shin OH, Esquivies L, Lin PY, White KI, Sun R, Chung WK, Monteggia LM, Brunger AT, Kavalali ET (2021). Role of aberrant spontaneous neurotransmission in SNAP25-associated encephalopathies. Neuron 109: 59-72.

For the list of all publications, please click here.