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Uddin Laboratory for Ocular Imaging

Publications

 

  1. Uddin, M.I.Imaging of the retinal hypoxia: A journey from oxygen microelectrode to the first hypoxia imaging in the living retina. Progress in Retinal and Eye Research, 2025  https://doi.org/10.1016/j.preteyeres.2025.101411).
  2. Uddin, M.I. Dieckmann, B.W.; Soliman, S.M. Novel optical imaging probe for the targeted visualization of NLRP3 inflammasomes in the living retina. Journal of Medicinal Chemistry 2025, 68, 15, 16034–16047. https://doi.org/10.1021/acs.jmedchem.5c00999
  3. Uddin, M.I.; Dieckmann, B.W.; Burgos, D. E. Imaging hypoxia in diabetic retina: A potential early detection imaging biomarker before any detectable retinopathy in diabetes. Diabetes 2025 (Accepted, In Press).
  1. Uddin, M.I.; Penn, J.S.Retinal hypoxia is an early detection imaging biomarker for diabetic retinopathy.                             American Journal of Pathology 2025, (Accepted, In Press).
  2. Jamal, S.Z.; Penn, J.S.; and Uddin, M.I. A direct method for imaging gradient levels of retinal hypoxia in a rat model of retinopathy of prematurity. J Trans Med. 2025 (under review).
  3. Imaging hypoxia to predict primary neuronal cell damage in branch retinal artery occlusion. Jamal, S.Z.; Dieckmann, B.W.; McCollum, G.W.; Penn, J.S.; Jayagopal A.; and Uddin, M.I.  Microcirculation (2024, 31(7):e12883. doi: 10.1111/micc.12883.
  4. Role of NLRP3 inflammasomes in monocyte and microglial recruitments in choroidal neovascularization. Dieckmann, B.W.; Paguaga, M.E.; Penn, J.P.; Uddin, M.I. ImmunoHorizons 2024, 8(5):363-370. https://doi.org/10.4049/immunohorizons.2400025
  5. A Method to Regulate Monocyte Function by Silencing HIF-1 mRNA in a Model of Retinal Neovascularization. Atalor, R.E.; Dieckmann, B.W.; Penn, J.S.; Uddin, M.I. ACS Applied Nano Materials 2023, 6, 24, 22939-22946. https://doi.org/10.1021/acsanm.3c04300
  6. A novel optical imaging probe for targeted visualization of NLRP3 inflammasomes in a mouse model of age-related macular degeneration. Paguaga, M.E.; Penn, J.S.; Uddin, M.I. Frontiers in Medicine 2023,https://doi.org/10.3389/fmed.2022.1047791.
  7. A novel method for visualizing and tracking endogenous mRNA in a specific cell population in pathological neovascularization. Uddin, M.I.; Kilburn, T.C.; Jamal, S.Z.; Duvall, C.L.; Penn, J.S. Scientific Reports 11 (1), 2565 (2021). https://doi.org/10.1038/s41598-021-81367-5
  8. Visualizing HIF-1α mRNA in a Subpopulation of Bone Marrow-Derived Cells to Predict Retinal Neovascularization. Uddin, M.I.; TC Kilburn, T.C.; Duvall, C.L.; Penn, J.S. ACS chemical biology 15 (11), 3004-3012 (2020). doi: 1021/acschembio.0c00662
  9. Emerging therapeutic modalities for diabetic retinopathy. Uddin, M.I.; Jayagopal, A. Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases (2020). https://link.springer.com/chapter/10.1007/7355_2020_101
  10. Discovery of furanone-based radiopharmaceuticals for diagnostic targeting of COX-1 in ovarian cancer. Uddin, M.J.; Wilson, A.J.; Crews, B.C.; Malerba, P.; Uddin, M.I.; Kingsley, P.J; … ACS omega 4 (5), 9251-9261 (2019). DOI: 10.1021/acsomega.9b01093
  11. Targeted imaging of VCAM-1 mRNA in a mouse model of laser-induced choroidal neovascularization using antisense hairpin-DNA-functionalized gold-nanoparticles. Uddin, M.I.; Kilburn, T.C.; Yang, R.; McCollum, G.W.; Wright, D.W.; Penn, J.S. Molecular pharmaceutics 15 (12), 5514-5520 (2018). doi: 1021/acs.molpharmaceut.8b00661
  12. Real-time imaging of VCAM-1 mRNA in TNF-α activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles. Uddin, M.I.; Jayagopal, A.; Wong, A.; McCollum, G.W.; Wright, D.W.; Penn, J.S. Nanomedicine: Nanotechnology, Biology and Medicine 14 (1), 63-71 (2018). DOI: 1016/j.nano.2017.08.018
  13. In vivo imaging of retinal hypoxia using hypox-4-dependent fluorescence in a mouse model of laser-induced retinal vein occlusion (RVO). Uddin, M.I.; Jayagopal, A.; McCollum, G.W.; Yang, R.; Penn, J.S. Invest. Ophthalmol. Vis. Sci. 58 (9), 3818-3824 (2017). doi: 1167/iovs.16-21187
  14. In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Uddin, M.I.; Evans, S.M.; Craft, J.R.; Capozzi, M.E.; McCollum, G.W.; Yang, R.; … Scientific Reports 6 (1), 31011 (2016). doi: 1038/srep31011
  15. Nanoengineering of therapeutics for retinal vascular disease. N Gahlaut, N.; Suarez, S.; Uddin, M.I.; Gordon, A.Y.; Evans, S.M.; Jayagopal, A. European Journal of Pharmaceutics and Biopharmaceutics 95, 323-330 (2015). doi: 1016/j.ejpb.2015.05.001
  16. Applications of azo-based probes for imaging retinal hypoxia. Uddin, M.I.; Evans, S.M.; Craft, J.R.; Marnett, L.J.; Uddin, M.J.; Jayagopal, A. ACS Medicinal Chemistry Letters 6 (4), 445-449 (2015). doi: 1021/ml5005206
  17. Synthesis of prodigiosene–estrogen conjugates: optimization of protecting group strategies and anticancer properties. Marchal, E.; Uddin, M.I.; Hawco, C.L.A.; Thompson, A. Canadian Journal of Chemistry 93 (5), 526-535(2015).
  18. Molecular probes for imaging of hypoxia in the retina. Evans, S.M.; Kim, K.; Moore, C.E.; Uddin, M.I.; Capozzi, M.E.; Craft, J.R.;… Bioconjugate chemistry 25 (11), 2030-2037 (2014). DOI: 1021/bc500400z
  19. Microwave-assisted, one-pot reaction of 7-azaindoles and aldehydes: a facile route to novel di-7-azaindolylmethanes. Uddin, M.I.; Buck, J.R.; Schulte, M.L.; Tang, D.; Saleh, S.A.; Cheung, Y.Y.; Harp, J.; …Tetrahedron letters 55 (1), 169-173 (2014). doi: 1016/j.tetlet.2013.10.143
  20. Synthesis and antimalarial activity of prodigiosenes. Marchal, E.; Smithen, D.A.; Uddin, M.I.; Robertson, A.W.; Jakeman, D.L.; Mollard, V.; … Organic & Biomolecular Chemistry 12 (24), 4132-4142 (2014). https://doi.org/10.1039/C3OB42548G
  21. Synthesis and biological evaluation of prodigiosene conjugates of porphyrin, estrone and 4-hydroxytamoxifen. Hawco, C.L.A.; Marchal, E.; Uddin, M.I.; Baker, A.E.G.; Corkery, D.P.; Dellaire, G.; … Bioorganic & medicinal chemistry 21 (19), 5995-6002 (2013). DOI: 1016/j.bmc.2013.07.042
  22. Synthesis and structure–activity relationships of 5, 6, 7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. Tang, D.; McKinley, E.T.; Hight, M.R.; Uddin, M.I.; Harp, J.M.; Fu, A.; Nickels, M.L.; … Journal of medicinal chemistry 56 (8), 3429-3433 (2013). DOI: 1021/jm4001874
  23. 3’-deoxy-3′-18F-fluorothymidine PET predicts response to V600EBRAF-targeted therapy in preclinical models of colorectal cancer. McKinley, E.T.; Smith, R.A.; Zhao, P.; Fu, A.; Saleh, S.A.; Uddin, M.I.; … Journal of Nuclear Medicine 54 (3), 424-430 (2013). DOI: 2967/jnumed.112.108456
  24. Synthetic prodigiosenes and the influence of C-ring substitution on DNA cleavage, transmembrane chloride transport and basicity. Rastogi, S.; Marchal, E.; Uddin, M.I.; Groves, B.; Colpitts, J.; McFarland, S.A.; … Organic & Biomolecular Chemistry 11 (23), 3834-3845 (2013). https://doi.org/10.1039/C3OB40477C
  25. Antimicrobial activity of non-natural prodigiosenes. Marchal, E.; Uddin, M.I.; Smithen, D.A.; Hawco, C.L.A.; Lanteigne, M.; Overy, D.P.; … Rsc Advances 3 (45), 22967-22971 (2013). https://doi.org/10.1039/C3RA45479G
  26. Rapid, microwave-assisted organic synthesis of selective V600EBRAF inhibitors for preclinical cancer research. Buck, J.R.; Saleh, S.A.; Uddin, M.I.; Manning, H.C. Tetrahedron letters 53 (32), 4161-4165 (2012). DOI: 1016/j.tetlet.2012.05.137
  27. Synthesis of heteroleptic pyrrolide/bipyridyl complexes of ruthenium (II). Lundrigan, T.; Jackson, C.L.M.; Uddin, M.I.; Tucker, L.A.; Ali, A.A.S.; Linden, A.; … Canadian Journal of Chemistry 90 (8), 693-700 (2012). https://doi.org/10.1139/v2012-045
  28. Improved synthetic route to C-ring ester-functionalized prodigiosenes. Uddin, M.I.; Thirumalairajan, S.; Crawford, S.M. Cameron, T.S.; Thompson, A. Synlett 2010 (17), 2561-2564 (2010). DOI: 10.1055/s-0030-1258769
  29. Microwave-assisted and Ln (OTf) 3-catalyzed homo-conjugate addition of N-heteroaromatics to activated cyclopropane derivatives. Uddin, M.I.; Mimoto, A.; Nakano, K.; Ichikawa, Y.; Kotsuki, H. Tetrahedron letters 49 (41), 5867-5870 (2008). https://doi.org/10.1016/j.tetlet.2008.07.142
  30. A Novel method for the high-pressure-promoted, uncatalyzed aza-Michael reaction of nitrogen heterocycles with enones in water. Uddin, M.I.; Nakano, K.; Ichikawa, Y.; Kotsuki, H. Synlett 2008 (09), 1402-1406 (2008). DOI: 10.1055/s-2008-1072594
  31. Synthesis and preliminary evaluation of brominated 5-methyl-2, 4-dihydropyrazol-3-one and its derivatives as cytotoxic agents. Khan, R.; Uddin, M.I.; Alam, M.S.; Hossain, M.M.; Islam, M.R. Bangladesh Journal of Pharmacology, 3 (1), 27-35 (2008). DOI: 10.3329/bjp.v3i1.834
  32. A novel design of roof-shaped anthracene-fused chiral prolines as organocatalysts for asymmetric Mannich reactions. Sasaoka, A.; Uddin, M.I.; Shimomoto, A.; Ichikawa, Y.; Shiro, M.; Kotsuki, H. Tetrahedron: Asymmetry 17 (21), 2963-2969 (2006). DOI: 1002/chin.200718039

 

Abstracts:

    1. Targeted Delivery of shRNA-lipids to activated monocytes and inhibition of neovascularization in proliferative retinopathy. Uddin, M.I. Diabetes 73:1464 (2024); (peer reviewed) https://doi.org/10.2337/db24-1464-P

 

Articles in refereed journals:

Journal  COVER  Release  

  1. Microcirculation

2024-10 | Journal article

DOI: 10.1111/micc.12892

CONTRIBUTORS: Jamal, S.Z.; Dieckmann, B.W.; McCollum, G.W.; Penn, J.S.; Jayagopal A.; and Uddin, M.I.

  1. ACS Chemical Biology

2020-10 | Journal article

Link: https://pubs.acs.org/toc/acbcct/15/11

CONTRIBUTORS: Uddin, M.I.; TC Kilburn, T.C.; Duvall, C.L.; Penn, J.S.