Patents

1. PATENT (Pending), Uddin, M.I. Attorney Docket No. 10644-147V1, 2023, https://patentscope.wipo.int/search/en/WO2023211929. WO2023211929A1

2. PATENT (Pending, 2022), Uddin, M.I.; Penn, J.S. GW McCollum. (2022) https://patentscope.wipo.int/search/en/detail.jsf?docId=US370126896&_cid=P10-MI6CFR-78683-1. US US20220233714A1

3. PATENT (Pending, 2020), Uddin, M.I.; Penn, J.S.; Duvall, CL. https://patentscope.wipo.int/search/en/WO2020219796. WO US WO2020219796A1

4. PATENT (Issued, 2020), Uddin, M.I.; Jayagopal, A.; Uddin, M.J.; Penn, J.S.; Marnett, L.J.

(June 2020) https://patentscope.wipo.int/search/en/WO2016179117. Patent US10695446 B2.

Composition And Method For Detecting Hypoxia

About the Patent

A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.

Probes for Detecting RNA and Methods of Use Thereof

Description of the Patent WO 2020/219796 A1:
Disclosed herein are probes and methods for the detection of RNAs and for the detection and treatment of neovascularization. The inventors have developed a novel lipid-shRNA conjugate that facilitates delivery of anti-sense (AS) oligonucleotides into target cells without using any transfection reagents.