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A combined approach exploring gene function based on worm-human orthology.


Tamas IIvica , Hodges E Emily , Dessi P Patrick , Johnsen R Robert , Vaz Gomes A Ana . BMC genomics. 2005 ; 6(). 65


Many aspects of the nematode Caenorhabditis elegans biology are conserved between invertebrates and vertebrates establishing this particular organism as an excellent genetic model. Because of its small size, large populations and self-fertilization of the hermaphrodite, functional predictions carried out by genetic modifications as well as RNAi screens, can be rapidly tested.