NovelFam3000--uncharacterized human protein domains conserved across model organisms.
AUTHORS
Kemmer
DDanielle ,
Podowski
RM Raf M ,
Arenillas
D David ,
Lim
J Jonathan ,
Hodges
E Emily ,
Roth
P Peggy ,
Sonnhammer
EL Erik L L ,
Höög
C Christer ,
Wasserman
WW Wyeth W .
BMC genomics. 2006 ; 7().
48
- PMID: 16533400[PubMed].
- PMCID: PMC1440326.
ABSTRACT
Despite significant efforts from the research community, an extensive portion of the proteins encoded by human genes lack an assigned cellular function. Most metazoan proteins are composed of structural and/or functional domains, of which many appear in multiple proteins. Once a domain is characterized in one protein, the presence of a similar sequence in an uncharacterized protein serves as a basis for inference of function. Thus knowledge of a domain’s function, or the protein within which it arises, can facilitate the analysis of an entire set of proteins.