August, 2002
Mechanism behind acute leukemia identified by VUMC researchers
Aug. 9, 2002—A fusion protein resulting from a faulty DNA exchange plays a key role in the development of acute leukemia in humans, Vanderbilt researchers reported recently. The protein, called AML1-ETO, disarms a tumor suppressor and allows circumvention of a powerful tumor checkpoint, freeing cells to experience uncontrolled growth and an extended lifespan. A reciprocal exchange, or...