International Fellow, Pharmacology
Susanne was a medical student at Semmelweis University in Hungary. She worked in a molecular endocrinology laboratory in her home country, where she investigates the functional role of GPCR dimerization, using bioinformatics and experimental methods.
Susanne was working in the lab during the summer of 2015, as a participant of the Vanderbilt Short-Term Fellowship Program.
Susanne was investigating the behaviour of different non-visual arrestin mutants with altered receptor specificity. The manipulation of the receptor-binding concave side can lead to the selective disruption or enhancement of individual arrestin-receptor interactions. She was testing the binding of several arrestin mutants to different GPCRs by in-cell BRET.
Papers from the lab
Toth, A.D., Prokop, S., Gyombolai, P., Varnai, P., Balla, A., Gurevich, V.V., Hunaydi, L., Turu, G. Heterologous phosphorylation-induced formation of a stability lock permits regulation of inactive receptors by b-arrestins. J Biol Chem, in press; doi: 10.1074/jbc.M117.813139 (2018).
Prokop, S., Perry, N.A., Vishnivetskiy, S.A., Toth, A.D., Inoue, A., Milligan, G., Iverson, T.M., Hunyady, L., Gurevich, V.V. Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors. Cell Signal 36, 98-107 (2017).