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Regina Jiweon Lee

Undergraduate Intern, Pharmacology

Vanderbilt University – Molecular and cellular biology major

Sophomore, the class of 2015.

Regina is originally from Indiana. She is on the executive board for the association of biology students. Among other things, Regina enjoys playing piano and cooking.

Upon graduation Regina did a one-year post-bac at NIH. Currently she entered medical school at the University of Indiana

Research Description

Regina is a sophomore, majoring in molecular and cellular biology. She is volunteering several hours per week to get research experience. Under supervision of Seva Gurevich and Sergey Vishnivetskiy she is constructing cysteine-free versions of enhanced bovine visual arrestin-1 for use in crystallography and EPR to elucidate the mechanisms of arrestin activation by receptors. She will continue by first functionally testing numerous mutants she makes with Sergey, and then by using them in biophysical and biochemical studies.

Vishnivetskiy, S.A., Lee, R.J., Zhou, X.E., Franz, A., Xu, Q., Xu, H.E., Gurevich, V.V. Functional role of the three conserved cysteines in the N-domain of visual arrestin-1. J Biol Chem, 292 (30), 12496-12502; doi: 10.1074/jbc.M117.790386 (2017).

Zhu, L., Rossi, M., Cui, Y., Lee, R.J., Sakamoto, W., Perry, N.A., Urs, N.M., Caron, M.G., Gurevich, V.V., Godlewski, G., Kunos, G., Chen, M., Chen, W., Wess, J. Hepatic b-arrestin-2 is essential for maintaining euglycemia. J Clin Invest , in press (2017).

Zhu, L., Almaça, J., Dadi, P.K., Hong, H., Sakamoto, W., Rossi, M., Lee, R.J., Vierra, N.C.  Lu, H., Cui, Y., McMillin, S.M., Perry, N.A., Gurevich, V.V., Lee, A., Kuo, B., Leapman, R.D., Matschinsky, F.M., Doliba, N.M., Urs, N.M., Caron, M.G., Jacobson, D.A., Caicedo, A., Wess, J. b-Arrestin-2 is an essential regulator of pancreatic b-cell function under physiological and pathophysiological conditions. Nat Commun 8, 14295; DOI 10.1038/NCOMMS14295 (2017).

Kang, Y., Zhou, X.E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T.A., Yefanov, O., Han, G.W., Xu, Q., de Waal, P.W., Ke, J., Tan, M.H.E., Zhang, C., Moeller, A., West, G.M., Van Eps, N., Caro, L.N., Vishnivetskiy, S.A., Lee, R.J., Suino-Powell, K.M., Gu, X., Pal, K., Ma, J., Zhi, X., Boutet, S., Williams, G.J., Messerschmidt, M., Gati, C., Zatsepin, N.A., Wang, D., James, D., Basu, S., Roy-Chowdhury, S., Conrad, C., Coe, J., Liu, H., Lisova, S., Kupitz, C., Grotjohnn, I., Fromme, R., Jiang, Y., Tasn, M., Yang, H., Li, J., Wang, M., Li, D., Zhao, Y., Standfuss, J., Diederichs, K., Potter, C.S., Carragher, B., Caffrey, M., Jiang, H., Chapman, H.N., Spence, J.C.H., Fromme, P., Weierstall, U., Ernst, O.P., Gurevich, V.V., Griffin, P.R., Hubbell, W.L., Stevens, R.C., Cherezov, V., Melcher, K., Xu, H.E. Crystal structure of rhodopsin bound to arrestin determined by femtosecond X-ray laser. Nature, 523( 7562):561-7. doi: 10.1038/nature14656 (2015).