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Qiuyan Chen

Graduate Student, Pharmacology


Education

Qiuyan received B.S. in Biotechnology at Tongji University, China

Qiuyan defended her PhD thesis on October 1, 2015

She decided to stay for a short period as a post-doc to finish a number of projects and publish several papers describing those results. From June 1, 2016, she moved as a post-doc to John Tesmer’s lab (first to the University of Michigan, Ann Arbor, then to Purdue University). As of the end of 2021 she published six papers from John Tesmer’s lab, including groundbreaking structure of GRK1 in complex with rhodopsin in Nature. Currently Assistant Professor position at Indiana University.

Research Description

Research

Qiuyan worked in the lab 2011-2016  (co-mentored with Dr. Tina Iverson). She worked on several approaches to elucidate the structural basis of arrestin interaction with receptors and other signaling proteins. She is using every cutting-edge technique you can think of (and quite a few you can’t even think of). She presented collaborative work with Dr. Sanders lab at 2011 Cold Spring Harbor Asia conference in Suzhou, right after joining the lab. Qiuyan have been selected as a VISP (Vanderbilt International Scholar Program) scholar for 2011 and 2012.

Honors and awards

2011-2012 – Vanderbilt International Scholar Program Award

2011 Travel award for GPCR Workshop Dec 4-8, 2011, Maui, Hawaii
2011 – Pharmacology Retreat Talk, 2nd place

Publications from the lab:

Perry-Hauser, N.A., Kaoud, T.S., Stoy, H., Zhan, X., Chen, Q., Dalby, K.N., Iverson, T.M., Gurevich, V.V., Gurevich, E.V. Short arrestin-3 derived peptides activate JNK3 in cells. Int J Mol Sci 23 (15), 8679; doi: 10.3390/ijms23158679 (2022).

Chen, Q., Zhuo, Y., Sharma, P., Perez, I., Francis, D.J., Chakravarthy, S., Vishnivetskiy, S.A., Berndt, S., Hanson, S.M., Zhan, X., Brooks, E.K., Altenbach, C., Hubbell, W.L., Klug, C.S., Iverson, T.M., Gurevich, V.V. An eight amino acid segment controls oligomerization and preferred conformation of the two non-visual arrestins. J Mol Biol 433 (4), 166790; doi: 10.1016/j.jmb.2020.166790 (2021).

Perry, N.A., Kaoud, T.S., Ortega, O.O., Kaya, A.I., Marcus, D.J., Pleinis, J.M., Berndt, S., Chen, Q., Zhan, X., Dalby, K.N., Lopez, C.F., Iverson, T.M., Gurevich, V.V. Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification. Proc Natl Acad Sci USA, in press (2019).

Chen, Q., Iverson, T.M., Gurevich, V.V. Structural basis of arrestin-dependent signal transduction. Trends Biochem Sci 43 (6), 412-423 (2018).

Tso, S.-C., Chen, Q., Vishnivetskiy, S.A., Gurevich, V.V., Iverson T.M., Brautigam, C.A. Using two-site binding models to analyze microscale thermophoresis data. Anal Biochem 540-541, 64-75; doi: 10.1016/j.ab.2017.10.013 (2018).

Chen, Q., Perry, N.A., Vishnivetskiy, S.A., Berndt, S., Gilbert, N.C., Zhuo, Y., Singh, P.K., Tholen, J., Ohi, M.D., Gurevich, E.V., Brautigam, C.A., Klug, C.S., Gurevich, V.V., Iverson, T.M. Structural basis of arrestin-3 activation and signaling. Nat Commun 8 (1), 1427; doi: 10.1038/s41467-01701218-8 (2017).

Zhan, X., Stoy, H., Kaoud, T.S., Perry, N.A., Chen, Q., Perez, A., Els-Heindl, S., Slagis, J.V., Iverson, T.M., Beck-Sickinger, A.G., Gurevich, E.V., Dalby, K.N., Gurevich, V.V. Peptide mini-scaffold facilitates JNK3 activation in cells. Sci Rep 6, 21025; doi: 10.1038/srep21025 (2016).

Chen, Q., Vishnivetskiy, S.A., Zhuang, T., Cho, M.-K., Thaker, T.M., Sanders, C.R., Gurevich, V.V., Iverson, T.M. The rhodopsin-arrestin-1 interaction in bicelles. Chapter 6 in Rhodopsin: Methods and Protocols (Beata Jastrzebska, ed.), Methods in Molecular Biology, vol. 1271, pp. 77-95; Springer, New York (2015).

Vishnivetskiy S.A., Zhan, X., Chen, Q., Iverson, T.M., Gurevich VV. Arrestin expression in E. coli and purification. Curr Protoc Pharmacol 67, 2.11.1-2.11.19 (2014).

Chen, Q., Zhuo, Y., Kim, M., Hanson, S.M., Vishnivetskiy, S.A., Altenbach, C., Klug, C.S., Hubbell, W.L., and Gurevich, V.V. Self-association of arrestin family members. In: Arrestins – Pharmacology and Therapeutic Potential. Handb Exp Pharmacol 219, p. 205-223, Springer-Verlag, Berlin-Heidelberg (2014).

Song, X., Seo, J., Baameur, F., Vishnivetskiy, S.A., Chen, Q., Kook, S., Kim, M., Brooks, E.K., Altenbach, C., Hong, Y., Hanson, S.M., Palazzo, M.C., Chen, J., Hubbell, W.L., Gurevich, E.V., Gurevich, V.V. Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant. Cell Signal 25, 2613-2624 (2013).

Zhuang, T., Chen, Q., Cho, M.-K., Vishnivetskiy, S.A., Iverson, T.M., Gurevich*, V.V., Sanders*, C.R. (*corresponding authors). Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin. Proc. Natl. Acad. Sci. USA 110 (3), 942-947 (2013).

Vishnivetskiy, S.A., Chen, Q., Palazzo, M.C., Brooks, E.K., Altenbach, C., Iverson, T.M., Hubbell, W.L., Gurevich, V.V. Engineering visual arrestin-1 with special functional characteristics. J Biol Chem 288 (5), 3394-3405 (2013).

 

International meeting presentation:

Chen, Q., Zhuang, T., Vishnivetskiy, S., Gurevich, V. and Sanders C. (2011). Screening of membrane mimics for arrestin-1. Abstract for Cold Spring Harbor Asia Conferences – Membrane Proteins: Structure & Function