Undergraduate volunteer, August 2012-May 2013, Pharmacology
Senior in Biomedical Engineering at Vanderbilt. Graduated in 2013
Kristen is originally from Idaho. Currently lives in Saudi Arabia. Member of the Vanderbilt XC and track teams. Enjoys live music, the outdoors, and life on the edge.
Kristen was a senior Biomedical Engineering student at Vanderbilt interested in basic research, particularly in the field of vision. Kristen was volunteering several hours per week to get research experinece. Under supervision of Sergey Vishnivetskiy she was working on the structural and functional role of one of the loops in the central crest of receptor-binding side of arrestins. She made constructs transferring loop deletions and mutations affecting loop interactions with the rest of the molecule onto wild type mouse arrestin-1 background. She generated mRNA of these arrestins and determined their binding to different functional forms of rhodopsin. In addition, she tested thermal stability of these mutants.
Publications from the lab:
Vishnivetskiy, S.A., Baameur, F., Findley, K.R., Gurevich, V.V. Critical role of central 139-loop in stability and binding selectivity of arrestin-1. J Biol Chem 288 (17), 11741-50 (2013).