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Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis.


Clément AAurélie , Solnica-Krezel L Lilianna , Gould KL Kathleen L . Developmental dynamics : an official publication of the American Association of Anatomists. 2012 12 ; 241(12). 1911-21


Cyclin-dependent kinases (Cdks) and their counteracting phosphatases are key regulators of cell cycle progression. In yeasts, the Cdc14 family of phosphatases promotes exit from mitosis and progression through cytokinesis by reversing phosphorylation of Cdk1 substrates. In vertebrates, CDC14 paralogs, CDC14A and CDC14B, have so far been implicated in processes ranging from DNA damage repair, meiosis, centrosome duplication to ciliogenesis. However, the question of whether CDC14 paralogs can functionally compensate for each other has yet to be addressed.