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Gould Lab

Linking up at the BAR: oligomerization and F-BAR protein function.

AUTHORS

McDonald NANathan A , Gould KL Kathleen L . Cell cycle (Georgetown, Tex.). 2016 5 31; ().

ABSTRACT

As cells grow, move, and divide, they must reorganize and rearrange their membranes and cytoskeleton. The F-BAR protein family links cellular membranes with actin cytoskeletal rearrangements in processes including endocytosis, cytokinesis, and cell motility. Here we review emerging information on mechanisms of F-BAR domain oligomerization and membrane binding, and how these activities are coordinated with additional domains to accomplish scaffolding and signaling functions.