Small molecule Mcl-1 inhibitors for the treatment of cancer.
AUTHORS
Belmar
JJohannes ,
Fesik
SWStephen W .
Pharmacology & therapeutics. 2015 1 ; 145().
76-84
- PMID: 25172548[PubMed].
- PMCID: PMC4340597.
- NIHMSID: NIHMS629203
ABSTRACT
The Bcl-2 family of proteins serves as primary regulators of apoptosis. Myeloid cell leukemia 1 (Mcl-1), a pro-survival member of the Bcl-2 family of proteins, is overexpressed and the Mcl-1 gene is amplified in many tumor types. Moreover, the overexpression of Mcl-1 is the cause of resistance to several chemotherapeutic agents. Thus, Mcl-1 is a promising cancer target. This review highlights the current progress on the discovery of small molecule Mcl-1 inhibitors.