Arrojo e Drigo Laboratory

Dos Santos Cristiane , Cambraia Amanda , Shrestha Shristi , Cutler Melanie , Cottam Matthew , Perkins Guy , Lev-Ram Varda , Roy Birbickram , Acree Christopher , Kim Keun-Young , Deerinck Thomas , Dean Danielle , Cartailler Jean-Philippe , MacDonald E , Hetzer Martin , Ellisman Mark , Arrojo E Drigo Rafael , Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice Nat Commun. 2024 Oct 21;

Ma Zhibo , Lytle K , Chen Bob , Jyotsana Nidhi , Weiser Novak Sammy , Cho J , Caplan Leah , Ben-Levy Olivia , Neininger C , Burnette T , Trinh Q , Tan C B , Patterson A , Arrojo E Drigo Rafael , Giraddi R , Ramos Cynthia , Means L , Matsumoto Ichiro , Manor Uri , Mills C , Goldenring R , Lau S , Wahl M , DelGiorno E , Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury Gastroenterology. 2022 Feb 16;

Dai Xiao-Qing , Camunas-Soler Joan , Briant J B , Dos Santos Theodore , Spigelman F , Walker M , Arrojo E Drigo Rafael , Bautista Austin , Jones C , Avrahami Dana , Lyon James , Nie Aifang , Smith Nancy , Zhang Yongneng , Johnson Janyne , Manning Fox E , Michelakis D , Light E , Kaestner H , Kim K , Rorsman Patrik , Stein W , Quake R , MacDonald E , Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state Cell Metab. 2022 Feb 1;

Nathan C Winn C , Cottam A , Bhanot Monica , Caslin L , Garcia N , Arrojo E Drigo Rafael , Hasty H , Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity Diabetes. 2022 Nov 1;

Shrestha Shristi , Erikson Galina , Lyon James , Spigelman F , Bautista Austin , Manning Fox E , Dos Santos Cristiane , Shokhirev Maxim , Cartailler Jean-Philippe , Hetzer W , MacDonald E , Arrojo E Drigo Rafael , Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress Sci Adv. 2022 Oct 7;

Arrojo E Drigo Rafael , Probing β-Cell Biology in Space and Time Diabetes. 2021 Oct 7;

Krishna Shefali , Arrojo E Drigo Rafael , Capitanio S , Ramachandra Ranjan , Ellisman Mark , Hetzer W , Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain Dev Cell. 2021 Nov 8;

Arrojo e Drigo Rafael , Roy Birbickram , MacDonald Patrick , Molecular and functional profiling of human islets: from heterogeneity to human phenotypes Diabetologia. 2020 Sep ; 10 (63).

Arrojo e Drigo Rafael , Erickson Galina , Tyagi Swati , Capitanio Juliana , Lyon James , Spiegelman Aliya , Bautista Austin , Manning-Fox Jocelyn , Shokhriev Maxim , MacDonald Patrick , Hetzer Martin , Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific bioRxiv. 2019 Jan ;

Arrojo e Drigo Rafael , Jacob Stefan , Garcia-Pietro Concha , Zheng Xiaofeng , Fukuda Masahiro , Thi Nhu Hoa Tran , Stelmashenko Olga , Martins Pecanha Flavia Leticia , Rodriguez-Diaz Rayner , Bushong Eric , Deerinck Thomas , Phan Sebastien , Ali Yusuf , Leibiger Ingo , Chua Minni , Boudier Thomas , Song Sang-Ho , Graf Martin , Augustine Geroge , Ellisman Mark , Berggren Per-Olof , Structural basis for delta cell paracrine regulation in pancreatic islets Nature Communications. 2019 Aug ; 10

Arrojo e Drigo Rafael , Lev-Ram Varda , Tyagi Swati , Ramachandra Ranjan , Deerinck Thomas , Bushong Eric , Phan Sebastien , Orphan Victoria , Lechene Claude , Ellisman Mark , Hetzer Martin , Age Mosaicism across Multiple Scales in Adult Tissues Cell Metabolism. 2019 Aug ; 6 (2).

Toyama Brandon , Arrojo e Drigo Rafael , Lev-Ram Varda , Ramachandra Ranjan , Deerinck Thomas , Lechene Claude , Ellisman Mark , Hetzer Martin , Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells Journal of Cell Biology. 2018 Dec 14; 2 (218).

Diez Juan , Arrojo e Drigo Rafael , Zheng Xiaofeng , Stelmashenko Olga , Chua Minni , Rodriguez-Diaz Rayner , Fukuda Masahiro , Kohler Martin , Leibiger Ingo , Bo Bo Tun Sai , Ali Yusuf , Augustine George , Barathi Veluchamy , Berggren Per-Olof , Pancreatic Islet Blood Flow Dynamics in Primates Cell Reports. 2017 Aug 8; 20

Arrojo e Drigo Rafael , Ali Yusuf , Diez Juan , Kumar Srinivasan Dinesh , Berggren Per-Olof , Boehm Bernhard , New insights into the architecture of the islet of Langerhans: a focused cross-species assessment Diabetologia. 2015 Oct 1; 58 (10).