{"id":2,"date":"2024-07-09T18:13:49","date_gmt":"2024-07-09T18:13:49","guid":{"rendered":"https:\/\/lab.prd.vanderbilt.edu\/coate-lab\/?page_id=2"},"modified":"2025-07-31T19:23:12","modified_gmt":"2025-07-31T19:23:12","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/lab.vanderbilt.edu\/coate-lab\/","title":{"rendered":"Home Page"},"content":{"rendered":"<h1 style=\"text-align: center\">Translating islet biology into diabetes breakthroughs<\/h1>\n<p class=\"p1\">The Coate Lab investigates how adult pancreatic islet \u03b2- and \u03b1-cells preserve their specialized identity and hormone secretion &#8211; and why these defenses collapse in diabetes. We utilize a variety of state-of-the-art approaches in primary human islets, including CRISPR- and RNAi-edited \u201cpseudoislets,\u201d dynamic secretion assays, single-cell and bulk multi-omics, advanced imaging, and in-vivo xenografts to chart the transcription factor circuits and lipid signaling pathways disrupted earliest by metabolic stress. Our emphasis on human-focused methodologies ensures our findings are directly translatable and will inform precision therapies that safeguard functional \u03b2-cell mass and improve outcomes for adults with diabetes.<\/p>\n<p class=\"p1\">We foster an interactive lab culture built on scientific curiosity, personal and professional integrity, excellence, and lifelong learning. If you\u2019d like to join our dynamic team, please contact Dr. Coate at kathryn.coate@vanderbilt.edu.<\/p>\n<h4 style=\"text-align: left\"><strong>We are proudly affiliated with:<\/strong><\/h4>\n<ul>\n<li><a href=\"https:\/\/medschool.vanderbilt.edu\/mpb\/\" target=\"_blank\" rel=\"noopener\">Department of Molecular Physiology and Biophysics<\/a><\/li>\n<li><a href=\"https:\/\/medschool.vanderbilt.edu\/basic-sciences\/\" target=\"_blank\" rel=\"noopener\">School of Medicine Basic Sciences<\/a><\/li>\n<li><a href=\"https:\/\/medicine.vumc.org\/divisions\/diabetes-endocrinology-metabolism\" target=\"_blank\" rel=\"noopener\">VUMC Division of Diabetes, Endocrinology, and Metabolism<\/a><\/li>\n<li><a href=\"https:\/\/www.va.gov\/tennessee-valley-health-care\/locations\/nashville-va-medical-center\/\" target=\"_blank\" rel=\"noopener\">Department of Veterans Affairs, Tennessee Valley Healthcare System<\/a><\/li>\n<li><a href=\"https:\/\/www.vumc.org\/vdrc\/home\" target=\"_blank\" rel=\"noopener\">Vanderbilt Diabetes Research and Training Center<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Translating islet biology into diabetes breakthroughs The Coate Lab investigates how adult pancreatic islet \u03b2- and \u03b1-cells preserve their specialized identity and hormone secretion &#8211; and why these defenses collapse in diabetes. We utilize a variety of state-of-the-art approaches in primary human islets, including CRISPR- and RNAi-edited \u201cpseudoislets,\u201d dynamic secretion assays, single-cell and bulk multi-omics,&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"_acf_changed":false,"jetpack_post_was_ever_published":false,"footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"class_list":["post-2","page","type-page","status-publish","hentry"],"acf":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/PfTW5q-2","_links":{"self":[{"href":"https:\/\/lab.vanderbilt.edu\/coate-lab\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.vanderbilt.edu\/coate-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.vanderbilt.edu\/coate-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/coate-lab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/coate-lab\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":45,"href":"https:\/\/lab.vanderbilt.edu\/coate-lab\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":528,"href":"https:\/\/lab.vanderbilt.edu\/coate-lab\/wp-json\/wp\/v2\/pages\/2\/revisions\/528"}],"wp:attachment":[{"href":"https:\/\/lab.vanderbilt.edu\/coate-lab\/wp-json\/wp\/v2\/media?parent=2"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lab.vanderbilt.edu\/coate-lab\/wp-json\/wp\/v2\/tags?post=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}