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Chiang Lab Publications

2018

Cheng FY , Fleming JT , Chiang C , Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture Developmental biology. 2018 May 21; 440 (2). 152-166

2017

Ryan KE , Kim PS , Fleming JT , Brignola E , Cheng FY , Litingtung Y , Chiang C , Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex Developmental biology. 2017 Sep 30; 432 (1). 165-177

2016

Leto K , Arancillo M , Becker EB , Buffo A , Chiang C , Ding B , Dobyns WB , Dusart I , Haldipur P , Hatten ME , Hoshino M , Joyner AL , Kano M , Kilpatrick DL , Koibuchi N , Marino S , Martinez S , Millen KJ , Millner TO , Miyata T , Parmigiani E , Schilling K , Sekerkov√° G , Sillitoe RV , Sotelo C , Uesaka N , Wefers A , Wingate RJ , Hawkes R , Consensus Paper: Cerebellar Development. Cerebellum (London, England). 2016 Dec ; 15 (6). 789-828
Loganathan SN , Tang N , Fleming JT , Ma Y , Guo Y , Borinstein SC , Chiang C , Wang J , BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanis… Oncotarget. 2016 Jul 12; 7 (28). 43504-43517

2015

Williams CH , Hempel JE , Hao J , Frist AY , Williams MM , Fleming JT , Sulikowski GA , Cooper MK , Chiang C , Hong CC , An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for he… Cell reports. 2015 Apr 7; 11 (1). 43-50
Fleming J , Chiang C , The Purkinje neuron: A central orchestrator of cerebellar neurogenesis. Neurogenesis (Austin, Tex.). 2015 ; 2 (1). e1025940

2014

Jin D , Ni TT , Sun J , Wan H , Amack JD , Yu G , Fleming J , Chiang C , Li W , Papierniak A , Cheepala S , Conseil G , Cole SP , Zhou B , Drummond IA , Schuetz JD , Malicki J , Zhong TP , Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nature cell biology. 2014 Sep ; 16 (9). 841-51
Chiang Chin , Ihrie Rebecca , Controlling COR Competence: BCL-6 Regulates Neurogenesis and Tumor Suppression Cancer Cell. 2014 Dec 8; 26 773-4

2013

Fleming JT , He W , Hao C , Ketova T , Pan FC , Wright CC , Litingtung Y , Chiang C , The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar pr… Developmental cell. 2013 Nov 11; 27 (3). 278-92
Liu J , Li Q , Kuehn MR , Litingtung Y , Vokes SA , Chiang C , Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phal… Developmental biology. 2013 Mar 15; 375 (2). 160-71

2012

Ryan KE , Chiang C , Hedgehog secretion and signal transduction in vertebrates. The Journal of biological chemistry. 2012 May 25; 287 (22). 17905-13
Benesh AE , Fleming JT , Chiang C , Carter BD , Tyska MJ , Expression and localization of myosin-1d in the developing nervous system. Brain research. 2012 Feb 27; 1440 9-22
Murphy AJ , Li Y , Pietsch JB , Chiang C , Lovvorn HN , Mutational analysis of NOG in esophageal atresia and tracheoesophageal fistula patients. Pediatric surgery international. 2012 Apr ; 28 (4). 335-40
Cheng FY , Huang X , Sarangi A , Ketova T , Cooper MK , Litingtung Y , Chiang C , Widespread contribution of Gdf7 lineage to cerebellar cell types and implications for hedgehog-drive… PloS one. 2012 ; 7 (4). e35541
Huang X , Dubuc AM , Hashizume R , Berg J , He Y , Wang J , Chiang C , Cooper MK , Northcott PA , Taylor MD , Barnes MJ , Tihan T , Chen J , Hackett CS , Weiss WA , James CD , Rowitch DH , Shuman MA , Jan YN , Jan LY , Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via … Genes & development. 2012 Aug 15; 26 (16). 1780-96

2011

Mason TA , Kolobova E , Liu J , Roland JT , Chiang C , Goldenring JR , Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disrupt… PloS one. 2011 ; 6 (11). e27699

2010

Huang X , Sarangi A , Ketova T , Litingtung Y , Cooper MK , Chiang C , Intracranial orthotopic allografting of medulloblastoma cells in immunocompromised mice. Journal of visualized experiments : JoVE. 2010 ; (44).
Huang X , Ketova T , Litingtung Y , Chiang C , Isolation, enrichment, and maintenance of medulloblastoma stem cells. Journal of visualized experiments : JoVE. 2010 ; (43).
Huang X , Liu J , Ketova T , Fleming JT , Grover VK , Cooper MK , Litingtung Y , Chiang C , Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proceedings of the National Academy of Sciences of the United States of America. 2010 May 4; 107 (18). 8422-7

2009

Huang X , Ketova T , Fleming JT , Wang H , Dey SK , Litingtung Y , Chiang C , Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid ple… Development (Cambridge, England). 2009 Aug ; 136 (15). 2535-43
Oh S , Huang X , Liu J , Litingtung Y , Chiang C , Shh and Gli3 activities are required for timely generation of motor neuron progenitors. Developmental biology. 2009 Jul 15; 331 (2). 261-9

2008

Fogel JL , Chiang C , Huang X , Agarwala S , Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedge… Developmental dynamics : an official publication of the American Association of Anatomists. 2008 May ; 237 (5). 1359-72
Huang X , Goudy SL , Ketova T , Litingtung Y , Chiang C , Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Developmental dynamics : an official publication of the American Association of Anatomists. 2008 Oct ; 237 (10). 3079-87
Li Y , Gordon J , Manley NR , Litingtung Y , Chiang C , Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Developmental biology. 2008 Oct 1; 322 (1). 145-55

2007

Guerrero I , Chiang C , A conserved mechanism of Hedgehog gradient formation by lipid modifications. Trends in cell biology. 2007 Jan ; 17 (1). 1-5
Zhang H , Lawson WE , Polosukhin VV , Pozzi A , Blackwell TS , Litingtung Y , Chiang C , Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in … The American journal of pathology. 2007 Oct ; 171 (4). 1113-26
Huang X , Litingtung Y , Chiang C , Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telence… Development (Cambridge, England). 2007 Jun ; 134 (11). 2095-105
Huang X , Litingtung Y , Chiang C , Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for h… Human molecular genetics. 2007 Jun 15; 16 (12). 1454-68
Li Y , Litingtung Y , Ten Dijke P , Chiang C , Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia. Developmental dynamics : an official publication of the American Association of Anatomists. 2007 Mar ; 236 (3). 746-54

2006

Li Y , Zhang H , Litingtung Y , Chiang C , Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proceedings of the National Academy of Sciences of the United States of America. 2006 Apr 25; 103 (17). 6548-53

2005

Oh S , Huang X , Chiang C , Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Developmental dynamics : an official publication of the American Association of Anatomists. 2005 Nov ; 234 (3). 489-96
Takamoto N , You LR , Moses K , Chiang C , Zimmer WE , Schwartz RJ , DeMayo FJ , Tsai MJ , Tsai SY , COUP-TFII is essential for radial and anteroposterior patterning of the stomach. Development (Cambridge, England). 2005 May ; 132 (9). 2179-89
van Bokhoven H , Celli J , van Reeuwijk J , Rinne T , Glaudemans B , van Beusekom E , Rieu P , Newbury-Ecob RA , Chiang C , Brunner HG , MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold sy… Nature genetics. 2005 May ; 37 (5). 465-7

2004

Powles N , Marshall H , Economou A , Chiang C , Murakami A , Dickson C , Krumlauf R , Maconochie M , Regulatory analysis of the mouse Fgf3 gene: control of embryonic expression patterns and dependence … Developmental dynamics : an official publication of the American Association of Anatomists. 2004 May ; 230 (1). 44-56
Li Y , Zhang H , Choi SC , Litingtung Y , Chiang C , Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation d… Developmental biology. 2004 Jun 1; 270 (1). 214-31

2002

Perriton CL , Powles N , Chiang C , Maconochie MK , Cohn MJ , Sonic hedgehog signaling from the urethral epithelium controls external genital development. Developmental biology. 2002 Jul 1; 247 (1). 26-46
Litingtung Y , Dahn RD , Li Y , Fallon JF , Chiang C , Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature. 2002 Aug 29; 418 (6901). 979-83

2001

Chiang C , Litingtung Y , Harris MP , Simandl BK , Li Y , Beachy PA , Fallon JF , Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Developmental biology. 2001 Aug 15; 236 (2). 421-35

2000

Litingtung Y , Chiang C , Control of Shh activity and signaling in the neural tube. Developmental dynamics : an official publication of the American Association of Anatomists. 2000 Oct ; 219 (2). 143-54

1999

Chiang C , Swan RZ , Grachtchouk M , Bolinger M , Litingtung Y , Robertson EK , Cooper MK , Gaffield W , Westphal H , Beachy PA , Dlugosz AA , Essential role for Sonic hedgehog during hair follicle morphogenesis. Developmental biology. 1999 Jan 1; 205 (1). 1-9

1998

Litingtung Y , Lei L , Westphal H , Chiang C , Sonic hedgehog is essential to foregut development. Nature genetics. 1998 Sep ; 20 (1). 58-61

1996

Chiang C , Litingtung Y , Lee E , Young KE , Corden JL , Westphal H , Beachy PA , Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996 Oct 3; 383 (6599). 407-13