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Chen Lab

Recent Publications

Recent Publications (last 10 years)

 

2022

 

V.M. Ngwa, D.N. Edwards, Y. Hwang C. Yan, A. Richmond, D.M. Brantley-Sieders, and J. Chen (2022)

Loss of vascular endothelial glutaminase inhibits tumor growth and metastasis, and increases sensitivity to chemotherapy.  Cancer Res Commun (In press)

Wang-Bishop, L, Baljon, J.J., Wehbe, M., Madden, M.Z., Hanna, A., Becker, K.W., Garland, K.M., Wen, X., Shae, D., Edwards, D., Beckermann, K.E., Wolf, M., Delapp, R., Christov, P., Balko, J.M., Rathmell, J.C., Chen, J., Rathmell, W.K., and Wilson, J.T.. (2022)

STING-Activating Nanoparticles Reprogram the Vascular-Immune Interface to Amplify Responses to Cancer Immunotherapies.  Science Immunology (In revision).

2021

Chen J. HIF1a or HIF2a: Enhancing CD8+ T-cell Fitness for Antitumor Immunity. Cancer Immunol Res. 2021 Apr; 9(4): 364. PMID: 34003767, PII: 9/4/364, DOI: 10.1158/2326-6066.CIR-21-0114, ISSN: 2326-6074.

Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. J Clin Invest. 2021 Feb 2/15/2021; 131(4): PMID: 33320840, PMCID: PMC7880417, PII: 140100, DOI: 10.1172/JCI140100, ISSN: 1558-8238.

 

2020

Kim LC, Rhee CH, Chen J. RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1. Mol Cancer Res [print-electronic]. 2020 Aug 8/14/2020; PMID: 32801163, PII: 1541-7786.MCR-20-0262, DOI: 10.1158/1541-7786.MCR-20-0262, ISSN: 1557-3125.

Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J. Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity. JCI Insight. 2020 Aug 8/6/2020; 5(15): PMID: 32759497, PMCID: PMC7455083, PII: 139237, DOI: 10.1172/jci.insight.139237, ISSN: 2379-3708.

Song W, Kim LC, Han W, Hou Y, Edwards DN, Wang S, Blackwell TS, Cheng F, Brantley-Sieders DM, Chen J. Phosphorylation of PLC¿1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer. Mol Cancer Res [print-electronic]. 2020 Aug 8/4/2020; PMID: 32753469, PII: 1541-7786.MCR-20-0075, DOI: 10.1158/1541-7786.MCR-20-0075, ISSN: 1557-3125.

Shiuan E, Inala A, Wang S, Song W, Youngblood V, Chen J, Brantley-Sieders DM. Host deficiency in ephrin-A1 inhibits breast cancer metastasis. F1000Res. 2020; 9: 217. PMID: 32399207, PMCID: PMC7194498.2, DOI: 10.12688/f1000research.22689.2, ISSN: 2046-1402.

Shiuan EF, Song W, Wang S, Brantley-Sieders DM, and Chen J.  (2020) Tumor-specific EphA2 receptor tyrosine kinase inhibits anti-tumor immunity by recruiting suppressive myeloid populations in in NSCLC. BopRxiv doi: https://doi.org/10.1101/2020.05.08.084830

Yang, G., Song, W., Postoak, J.L., Chen, J., Martinez, J., Zhang, J., Wu, L., Van Kaer, L.  (2020) Autophagy-related protein Vps34 controls T cell metabolism and function.  Autophagy 16:1-12.

2019

Ngwa VM, Edwards DN, Philip M, Chen J. Microenvironmental Metabolism Regulates Antitumor Immunity. Cancer Res [print-electronic]. 2019 Aug 8/15/2019; 79(16): 4003-8. PMID: 31362930, PMCID: PMC6697577, PII: 0008-5472.CAN-19-0617, DOI: 10.1158/0008-5472.CAN-19-0617, ISSN: 1538-7445.

Hwang Y, Kim LC, Song W, Edwards DN, Cook RS, Chen J. Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth In Vivo. Cancer Res [print-electronic]. 2019 Jul 7/1/2019; 79(13): 3178-84. PMID: 31085701, PMCID: PMC6606357, PII: 0008-5472.CAN-18-3658, DOI: 10.1158/0008-5472.CAN-18-3658, ISSN: 1538-7445.

2018

Raybuck AL, Cho SH, Li J, Rogers MC, Lee K, Williams CL, Shlomchik M, Thomas JW, Chen J, Williams JV, Boothby MR. B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity. J. Immunol [print-electronic]. 2018 Apr 4/15/2018; 200(8): 2627-39. PMID: 29531165, PMCID: PMC5893413, PII: jimmunol.1701321, DOI: 10.4049/jimmunol.1701321, ISSN: 1550-6606.

2017

Edwards DN, Ngwa VM, Wang S, Shiuan E, Brantley-Sieders DM, Kim LC, Reynolds AB, Chen J. The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ. Sci Signal. 2017 Dec 12/5/2017; 10(508): PMID: 29208682, PMCID: PMC5819349, PII: 10/508/eaan4667, DOI: 10.1126/scisignal.aan4667, ISSN: 1937-9145.

Song W, Hwang Y, Youngblood VM, Cook RS, Balko JM, Chen J, Brantley-Sieders DM. Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers. Oncogene [print-electronic]. 2017 Oct 10/5/2017; 36(40): 5620-30. PMID: 28581527, PMCID: PMC5629103, PII: onc2017170, DOI: 10.1038/onc.2017.170, ISSN: 1476-5594.

Finney AC, Funk SD, Green JM, Yurdagul A, Rana MA, Pistorius R, Henry M, Yurochko A, Pattillo CB, Traylor JG, Chen J, Woolard MD, Kevil CG, Orr AW. EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis. Circulation [print-electronic]. 2017 Aug 8/8/2017; 136(6): 566-82. PMID: 28487392, PMCID: PMC5548618, PII: CIRCULATIONAHA.116.026644, DOI: 10.1161/CIRCULATIONAHA.116.026644, ISSN: 1524-4539.

Kim LC, Cook RS, Chen J. MTORC1 and mTORC2 in cancer and the tumor microenvironment. Oncogene [print-electronic]. 2017 Apr 4/20/2017; 36(16): 2191-201. PMID: 27748764, PMCID: PMC5393956, PII: onc2016363, DOI: 10.1038/onc.2016.363, ISSN: 1476-5594.

2016

Shiuan E, Chen J. Eph Receptor Tyrosine Kinases in Tumor Immunity. Cancer Res [print-electronic]. 2016 Nov 11/15/2016; 76(22): 6452-7. PMID: 27811149, PMCID: PMC5290221, PII: 0008-5472.CAN-16-1521, DOI: 10.1158/0008-5472.CAN-16-1521, ISSN: 1538-7445.

Youngblood VM, Kim LC, Edwards DN, Hwang Y, Santapuram PR, Stirdivant SM, Lu P, Ye F, Brantley-Sieders DM, Chen J. The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer. Cancer Res [print-electronic]. 2016 Apr 4/1/2016; 76(7): 1825-36. PMID: 26833123, PMCID: PMC4873477, PII: 0008-5472.CAN-15-0847, DOI: 10.1158/0008-5472.CAN-15-0847, ISSN: 1538-7445.

Amato KR, Wang S, Tan L, Hastings AK, Song W, Lovly CM, Meador CB, Ye F, Lu P, Balko JM, Colvin DC, Cates JM, Pao W, Gray NS, Chen J. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res [print-electronic]. 2016 Jan 1/15/2016; 76(2): 305-18. PMID: 26744526, PMCID: PMC4715957, PII: 0008-5472.CAN-15-0717, DOI: 10.1158/0008-5472.CAN-15-0717, ISSN: 1538-7445.

Takahashi K, Sumarriva K, Kim R, Jiang R, Brantley-Sieders DM, Chen J, Mernaugh RL, Takahashi T. Determination of the CD148-Interacting Region in Thrombospondin-1. PLoS ONE. 2016; 11(5): e0154916. PMID: 27149518, PMCID: PMC4858292, PII: PONE-D-15-55087, DOI: 10.1371/journal.pone.0154916, ISSN: 1932-6203.

Simonik EA, Cai Y, Kimmelshue KN, Brantley-Sieders DM, Loomans HA, Andl CD, Westlake GM, Youngblood VM, Chen J, Yarbrough WG, Brown BT, Nagarajan L, Brandt SJ. LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer). PLoS ONE. 2016; 11(10): e0164804. PMID: 27780223, PMCID: PMC5079595, PII: PONE-D-16-16733, DOI: 10.1371/journal.pone.0164804, ISSN: 1932-6203.

2015

Wang S, Amato KR, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders DM, Chen J. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways. Mol. Cell. Biol [print-electronic]. 2015 Apr; 35(7): 1299-313. PMID: 25582201, PMCID: PMC4355541, PII: MCB.00306-14, DOI: 10.1128/MCB.00306-14, ISSN: 1098-5549.

Youngblood V, Wang S, Song W, Walter D, Hwang Y, Chen J, Brantley-Sieders DM. Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium. Mol. Cancer Res [print-electronic]. 2015 Mar; 13(3): 524-37. PMID: 25504371, PMCID: PMC4416411, PII: 1541-7786.MCR-14-0142, DOI: 10.1158/1541-7786.MCR-14-0142, ISSN: 1557-3125.

Chen J, Song W, Amato K. Eph receptor tyrosine kinases in cancer stem cells. Cytokine Growth Factor Rev [print-electronic]. 2015 Feb; 26(1): 1-6. PMID: 24933439, PMCID: PMC4234705, PII: S1359-6101(14)00043-4, DOI: 10.1016/j.cytogfr.2014.05.001, ISSN: 1879-0305.

2014

McCormack DR, Walsh AJ, Sit W, Arteaga CL, Chen J, Cook RS, Skala MC. In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts. Biomed Opt Express. 2014 Jul 7/1/2014; 5(7): 2247-61. PMID: 25071962, PMCID: PMC4102362, PII: 210394, DOI: 10.1364/BOE.5.002247, ISSN: 2156-7085.

Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J. JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer. Cancer Res [print-electronic]. 2014 May 5/1/2014; 74(9): 2444-54. PMID: 24607842, PMCID: PMC4008716, PII: 0008-5472.CAN-13-2136, DOI: 10.1158/0008-5472.CAN-13-2136, ISSN: 1538-7445.

Amato KR, Wang S, Hastings AK, Youngblood VM, Santapuram PR, Chen H, Cates JM, Colvin DC, Ye F, Brantley-Sieders DM, Cook RS, Tan L, Gray NS, Chen J. Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC. J. Clin. Invest [print-electronic]. 2014 May; 124(5): 2037-49. PMID: 24713656, PMCID: PMC4001547, PII: 72522, DOI: 10.1172/JCI72522, ISSN: 1558-8238.

Takahashi K, Matafonov A, Sumarriva K, Ito H, Lauhan C, Zemel D, Tsuboi N, Chen J, Reynolds A, Takahashi T. CD148 tyrosine phosphatase promotes cadherin cell adhesion. PLoS ONE. 2014; 9(11): e112753. PMID: 25386896, PMCID: PMC4227875, PII: PONE-D-14-33624, DOI: 10.1371/journal.pone.0112753, ISSN: 1932-6203.

2013

Boissier P, Chen J, Huynh-Do U. EphA2 signaling following endocytosis: role of Tiam1. Traffic [print-electronic]. 2013 Dec; 14(12): 1255-71. PMID: 24112471, PMCID: PMC3859973, DOI: 10.1111/tra.12123, ISSN: 1600-0854.
O’Neal WT, Griffin WF, Dries JL, Kent S, Chen J, Willis MS, Virag, JAI. (2013) Ephrin-Eph signaling as a potential therapeutic target for the treatment of myocardial infarction.  Medical Hypotheses 80:738-44.

 

2012

Zhuang G, Song W, Amato K, Hwang Y, Lee K, Boothby M, Ye F, Guo Y, Shyr Y, Lin L, Carbone DP, Brantley-Sieders DM, Chen J. Effects of cancer-associated EPHA3 mutations on lung cancer. J. Natl. Cancer Inst [print-electronic]. 2012 Aug 8/8/2012; 104(15): 1182-97. PMID: 22829656, PMCID: PMC3611812, PII: djs297, DOI: 10.1093/jnci/djs297, ISSN: 1460-2105.

Hahn AS, Kaufmann JK, Wies E, Naschberger E, Panteleev-Ivlev J, Schmidt K, Holzer A, Schmidt M, Chen J, König S, Ensser A, Myoung J, Brockmeyer NH, Stürzl M, Fleckenstein B, Neipel F. The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi’s sarcoma–associated herpesvirus. Nat. Med. 2012 Jun; 18(6): 961-6. PMID: 22635007, PMCID: PMC3645317, PII: nm.2805, DOI: 10.1038/nm.2805, ISSN: 1546-170X.

Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M. Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. J. Exp. Med [print-electronic]. 2012 Apr 4/9/2012; 209(4): 713-28. PMID: 22473959, PMCID: PMC3328370, PII: jem.20111470, DOI: 10.1084/jem.20111470, ISSN: 1540-9538.

Funk SD, Yurdagul A, Albert P, Traylor JG, Jin L, Chen J, Orr AW. EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2012 Mar; 32(3): 686-95. PMID: 22247258, PMCID: PMC3325141, PII: ATVBAHA.111.242792, DOI: 10.1161/ATVBAHA.111.242792, ISSN: 1524-4636.

Chen J. Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases. Adv. Cancer Res. 2012; 114: 1-20. PMID: 22588054, PMCID: PMC3626259, PII: B978-0-12-386503-8.00001-6, DOI: 10.1016/B978-0-12-386503-8.00001-6, ISSN: 0065-230X.

Rao M, Song W, Jiang A, Shyr Y, Lev S, Greenstein D, Brantley-Sieders D, Chen J. VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity. PLoS ONE [print-electronic]. 2012; 7(10): e46281. PMID: 23049696, PMCID: PMC3462209, PII: PONE-D-12-16139, DOI: 10.1371/journal.pone.0046281, ISSN: 1932-6203.