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Lab Members

Seth Bordenstein, Ph.D., Centennial Endowed Chair in Biological Sciences

Dr. Bordenstein has studied animal-microbe symbioses and microbiomes for 25 years. He is an evolutionary geneticist and microbiologist in the Departments of Biological Sciences and Pathology, Microbiology, and Immunology at Vanderbilt University, Nashville, TN. He is the founding director of The Vanderbilt Microbiome Initiative and the worldwide HHMI-initiated science education program Discover the Microbes Within! The Wolbachia Project. He is also Associate Director of the Vanderbilt Institute for Infection, Immunology and Inflammation. His laboratory endeavors to understand the evolutionary and genetic principles that shape symbiotic interactions between animals, microbes, and viruses and the major applications of these interactions to human health. Towards these goals, the lab employs hypothesis-driven approaches to study intimate symbioses between arthropods and obligate intracellular bacteria that modify sexual reproduction and facultative symbioses between animals and gut microbes that impact animal health, fitness, and evolution. He is the recipient of the 2014 Jeffrey Nordhaus Award for Excellence in Undergraduate Teaching, 2014 Chancellor’s Award for Research, and 2018 Chancellor Faculty Fellow Award from Vanderbilt University.

Bordenstein CV 12/2019 | Google Scholar Profile | Twitter @Symbionticism | Blog Symbionticism | Seminars YouTube

Email: s.bordenstein(at)vanderbilt.edu / Phone: 615.322.9087


Sarah Bordenstein, M.S., Senior Research Specialist

Sarah co-leads the Bordenstein lab and is the Director of Discover the Microbes Within! The Wolbachia Project) in which she develops and disseminates worldwide educational resources related to symbiosis and biotechnology. She is an expert in microbial ecology, genomics, and science education. In her experimental work, she is using quantitative and computational genomic analyses to study phage WO and plasmid biology in Wolbachia.

Email: sarah.bordenstein(at)vanderbilt.edu | Phone: 615.322.9094 |  Twitter @srbordenstein


Brittany Leigh, Ph.D., Postdoc

Dr. Leigh (Website) joined the lab in September of 2017 to study the genetic and molecular bases of animal-bacteria-bacteriophage interactions, specifically cytoplasmic incompatibility caused by Wolbachia prophage WO genes in Drosophila melanogaster. CI is at the forefront of mosquito control efforts to curb the transmission of dengue and Zika viruses and is also a speciation mechanism between various arthropod species. Brittany holds the NIH F32 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship.

Email: brittany.a.leigh(at)vanderbilt.edu | Phone: 615.322.9094 | Twitter: @Britt_3Phage


Rupinder Kaur, Ph.D., Postdoc

Rupinder received her Ph.D. from University of Vienna, Austria in close collaboration with Edmund Mach Foundation, Italy and University of Cambridge, UK. Her broad scientific interests include host-Wolbachia-virus interactions. She joined the lab in December of 2019 and her main goal will be to undermine the mechanism and biochemical basis of the Wolbachia-induced drive system named Cytoplasmic Incompatibility (CI). CI is currently at the forefront of approaches targeting pest populations and mosquito-borne diseases. Outside of Science, she is all about traveling, playing pool, and card games.

Email: rupinder.kaur(@)vanderbilt.edu | Phone: 615.322.9094 | Twitter: @KaurTweets


Junhui Li, Ph.D., Postdoc

Junhui joined the lab in May of 2019 to explore how causative factors drive human microbiome development using multi-omic approaches and to establish causal links between diet, the microbiome, and metabolic health.
Email: junhui.li@vanderbilt.edu | Phone: 615.322.9094 | Twitter: @_JunhuiLi

Karissa Cross, Ph.D., Postdoc

Karissa obtained her Ph.D. from the University of Tennessee and Oak Ridge National Laboratory, and she joined the lab in June of 2019 to study the evolutionary and functional genetic basis of host-microbe and host-microbiota interactions. Her primary project examines what are the number and types of animal genes that regulate densities and maternal transmission of endosymbiotic bacteria (Wolbachia).

Email: karissa.cross(at)vanderbilt.edu | Phone: 615.322.9094 | Twitter: @Krisss_Crosss


Jessie Perlmutter, Graduate Student

Jessie (Website) joined the lab in 2015 to study the molecular genetics and mechanisms of how Wolbachia infections hijack animal reproduction. Her work centers on the genetic basis of male killing. Jessies holds the prestigous NIH F31 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship.

Email: jessamyn.i.perlmutter(at)vanderbilt.edu | Phone 615.322.9094 | Twitter @JIPerlmutter


Dylan Shropshire, Graduate Student

Dylan (Website) joined the lab in 2015 to study the microbial genetic basis of cytoplasmic incompatibility (CI). CI is at the forefront of mosquito control efforts to curb the transmission of dengue and Zika viruses. CI is also a speciation mechanism that assists the splitting of one species into two. Dylan holds the prestigious National Science Foundation Graduate Research Fellow.

Email: dylan.shropshire(at)vanderbilt.edu | Phone 615.322.9094 | Twitter @JediShropshire


 Caitlin Sprowls, M.S., Research Assistant

Caitlin started in the lab in February of 2018. Caitlin is responsible for laboratory safety, upkeep, insect husbandry, and stock supplies. She comes to Nashville from Galveston, TX.

Email: caitlin.sprowls(at)vanderbilt.edu | Phone: 615.322.9094 | Twitter: @caitowls


Emily Layton, Undergraduate Student

Emily (Class of 2020) joined the lab in 2016 under the guidance of Dylan Shropshire to study the microbial genetic basis and penetrance of cytoplasmic incompatibility. In December 2017, she was awarded a SyBBURE Searle Undergraduate Research Fellowship that supports her research in the lab.

Email: emily.m.layton(at)vanderbilt.edu | Phone: 615.322.9094 | Twitter: @emilymlayton


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Jane Myers, Undergraduate Student

Jane (Class of 2020) started in the lab in May of 2018 under the guidance of Jessie Perlmutter to study the genetic basis of male killing.

Email: jane.meyers(at)vanderbilt.edu / Phone: 615.322.9094

 


Mahip Profile

Mahip Kalra, Undergraduate Student

Mahip (Class of 2022) started in the lab in September of 2018 under the guidance of Dylan Shropshire to study the microbial genetic basis of cytoplasmic incompatibility (CI).

Email: mahip.kalra(at)vanderbilt.edu / Phone: 615.322.9094


Asia Miller, Undergraduate Student

Asia (Class of 2022) started in the lab in September of 2018 under the guidance of Teddy van Opstal to study the transmission of gut bacteria in Nasonia. In December 2018, she was awarded a SyBBURE Searle Undergraduate Research Fellowship that supports her research in the lab.

Email: asia.k.miller(at)vanderbilt.edu / Phone: 615.322.9094