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The Ascano Laboratory

A common polymorphism near PER1 and the timing of human behavioral rhythms.

AUTHORS

Lim ASAndrew S P , Chang AM Anne-Marie , Shulman JM Joshua M , Raj T Towfique , Chibnik LB Lori B , Cain SW Sean W , Rothamel K Katherine , Benoist C Christophe , Myers AJ Amanda J , Czeisler CA Charles A , Buchman AS Aron S , Bennett DA David A , Duffy JF Jeanne F , Saper CB Clifford B , De Jager PL Philip L . Annals of neurology. 2012 9 ; 72(3). 324-34

ABSTRACT

Circadian rhythms influence the timing of behavior, neurological diseases, and even death. Rare mutations in homologs of evolutionarily conserved clock genes are found in select pedigrees with extreme sleep timing, and there is suggestive evidence that certain common polymorphisms may be associated with self-reported day/night preference. However, no common polymorphism has been associated with the timing of directly observed human behavioral rhythms or other physiological markers of circadian timing at the population level.

Circadian rhythms influence the timing of behavior, neurological diseases, and even death. Rare mutations in homologs of evolutionarily conserved clock genes are found in select pedigrees with extreme sleep timing, and there is suggestive evidence that certain common polymorphisms may be associated with self-reported day/night preference. However, no common polymorphism has been associated with the timing of directly observed human behavioral rhythms or other physiological markers of circadian timing at the population level.

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