David C. Koomen
Graduate Student, The McLean Group
University of Tennessee – B.S. in Microbiology
University of South Florida – M.S. in Biotechnology
Background:
David was born and raised in Nashville, TN and attended the University of Tennessee in Knoxville, receiving his Bachelor’s in Microbiology. After graduating he took a job as a research assistant at H. Lee Moffitt Cancer Center in Tampa, FL studying drug resistance in multiple myeloma under the supervision of Ken H. Shain, MD, PhD. While working he continued his studies at the University of South Florida’s Morsani College of Medicine, receiving his Master’s in Biotechnology before coming to Vanderbilt to pursue a doctorate in Chemistry in the laboratory of Prof. John A. McLean.
David joined the McLean lab in January of 2021 and is currently characterizing and quantifying isomers of phase II sulfate and glucuronide steroids in athlete’s urine with liquid chromatography-ion mobility-mass spectrometry. He is also working on optimizing and quantifying metabolites and small molecules with LC-MS on a triple quadrupole mass spectrometer and hopes to expand on these projects by implementing metabolic flux experiments with pathway analysis.
Awards:
Mitchum Warren Fellowship, Vanderbilt University (August 2020 – June 2021)
Publications:
David C. Koomen,* Joy D. Guingab-Cagmat,* Paula S. Oliveira,* Bin Fang, Min Liu, Eric A. Welsh, Mark B. Meads, Tuan Nguyen, Laurel E. Meke, Steven A. Eschrich, Kenneth H. Shain, Timothy J. Garrett, John M. Koomen. “Proteometabolomics of Melphalan Resistance in Multiple Myeloma.” Methods in Molecular Biology. 2019 Vol. 1996, Chapter 21 *Equal Contributions PMID: 31127562 doi: 0.1007/978-1-4939-9488-5_21.
David C. Koomen, Mark B. Meads, Dario M. Magaletti, Joy D. Guingab-Cagmat, Paula S. Oliveira, Bin Fang, Min Liu, Eric A. Welsh, Laurel E. Meke, Zhijie Jiang, Oliver A. Hampton, Alexandre Tungesvik, Gabriel DeAvila, Raghunandan Reddy Alugubelli, Taiga Nishihori, Ariosto S. Silva, Steven A. Eschrich, Timothy J. Garrett, John M. Koomen, Kenneth H. Shain ”Metabolic Changes are Associated with Melphalan Resistance in Multiple Myeloma.“ J Proteome Res. 2021, May 20. PMID: 34014671 doi: 10.1021/acs.jproteome.1c00022
Don E. Davis, Jr., Katrina L. Leaptrot, David C. Koomen, Jody C. May, Gustavo de A. Cavalcanti, Monica C. Padilha, Henrique M.G. Pereira, John A. McLean. “Multidimensional Separations of Intact Phase II Steroid Metabolites Utilizing LC-Ion Mobility-MS” Anal Chem. Manuscript in review, May 2021.